Covariates in linkage analysis using sibling and cousin pairs

N. L. Saccone, N. Rochberg, R. J. Neuman, J. P. Rice

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Using simulated data from GAW 12, problem 2, we further develop a novel technique to detect and use significant covariates in linkage analysis. The method, first introduced by Rice et al. [Genet Epidemiol 17(Suppl. 1):S691-5, 1999], uses logistic regression to model perturbation in sharing as a function of covariate levels. The original method allows use of all sib pairs (concordant affected, concordant unaffected, and discordant). Here we extend this method to include cousin pairs in analysis.

Original languageEnglish
Pages (from-to)S540-S545
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
DOIs
StatePublished - 2001

Keywords

  • Allele-sharing methods
  • Identity by descent
  • Logistic regression
  • Relative pairs

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