Coupling planar cell polarity signaling to morphogenesis.

Jeffrey D. Axelrod, Helen McNeill

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling.

Original languageEnglish
Pages (from-to)434-454
Number of pages21
JournalTheScientificWorldJournal
Volume2
DOIs
StatePublished - Feb 15 2002
Externally publishedYes

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