Cost comparison of transcatheter and operative closures of ostium secundum atrial septal defects

Michael L. O'Byrne, Matthew J. Gillespie, Russell T. Shinohara, Yoav Dori, Jonathan J. Rome, Andrew C. Glatz

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background Clinical outcomes for transcatheter and operative closures of atrial septal defects (ASDs) are similar. Economic cost for each method has not been well described. Methods A single-center retrospective cohort study of children and adults<30 years of age undergoing closure for single secundum ASD from January 1, 2007, to April 1, 2012, was performed to measure differences in inflation-adjusted cost of operative and transcatheter closures of ASD. A propensity score weight-adjusted multivariate regression model was used in an intention-to-treat analysis. Costs for reintervention and crossover admissions were included in primary analysis. Results A total of 244 subjects were included in the study (64% transcatheter and 36% operative), of which 2% (n = 5) were ≥18 years. Crossover rate from transcatheter to operative group was 3%. Risk of reintervention (P =.66) and 30-day mortality (P =.37) were not significantly different. In a multivariate model, adjusted cost of operative closure was 2012 US $60,992 versus 2012 US $55,841 for transcatheter closure (P <.001). Components of total cost favoring transcatheter closure were length of stay, medications, and follow-up radiologic and laboratory testing, overcoming higher costs of procedure and echocardiography. Professional costs did not differ. The rate of 30-day readmission was greater in the operative cohort, further increasing the cost advantage of transcatheter closure. Sensitivity analyses demonstrated that costs of follow-up visits influenced relative cost but that device closure remained favorable over a broad range of crossover and reintervention rates. Conclusion For single secundum ASD, cost comparison analysis favors transcatheter closure over the short term. The cost of follow-up regimens influences the cost advantage of transcatheter closure.

Original languageEnglish
Pages (from-to)727-735.e2
JournalAmerican heart journal
Issue number5
StatePublished - May 1 2015


Dive into the research topics of 'Cost comparison of transcatheter and operative closures of ostium secundum atrial septal defects'. Together they form a unique fingerprint.

Cite this