Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production

D. S. Snyder, E. R. Unanue

Research output: Contribution to journalArticlepeer-review

534 Scopus citations

Abstract

Corticosteroids have profound effects on functions of the macrophage associated with antigen presentation to T cells. The drugs inhibited the expression of surface I-region-associated (Ia) antigens by peritoneal macrophages both in vitro and in vivo, reduced the production IL 1, and inhibited antigen presentation for T cell proliferation by macrophages. The doses of hydrocortisone and prednisolone that inhibited by 50% Ia expression in cultured macrophages ranged around 2 to 5 x 10-8 M. These results could explain one mechanism by which corticosteroids suppress the induction of immune responses.

Original languageEnglish
Pages (from-to)1803-1805
Number of pages3
JournalJournal of Immunology
Volume129
Issue number5
StatePublished - 1982

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