Cortical structural abnormalities in very preterm children at 7years of age

Yuning Zhang, Terrie E. Inder, Jeffrey J. Neil, Donna L. Dierker, Dimitrios Alexopoulos, Peter J. Anderson, David C. Van Essen

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


We analyzed long-lasting alterations in brain morphometry associated with preterm birth using volumetric and surface-based analyses applied to children at age 7. years. Comparison of 24 children born very preterm (VPT) to 24 healthy term-born children revealed reductions in total cortical gray matter volume, white matter volume, cortical surface area and gyrification index. Regional cortical shape abnormalities in VPT children included the following: shallower anterior superior temporal sulci, smaller relative surface area in the inferior sensori-motor cortex and posterior superior temporal cortex, larger relative surface area and a cingulate sulcus that was shorter or more interrupted in medial frontoparietal cortex. These findings indicate a complex pattern of regional vulnerabilities in brain development that may contribute to the diverse and long-lasting neurobehavioral consequences that can occur after very premature birth.

Original languageEnglish
Pages (from-to)469-479
Number of pages11
StatePublished - Apr 1 2015


  • Cortical surface
  • Folding
  • MRI
  • Relative surface area
  • Structural abnormality
  • Very preterm
  • Volume


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