Cortical folding is altered before surgery in infants with congenital heart disease

Cynthia Ortinau, Dimitrios Alexopoulos, Donna Dierker, David Van Essen, John Beca, Terrie Inder

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right lateral sulcus and left orbitofrontal region, cingulate region, and central sulcus. These abnormalities were present prior to surgery.

Original languageEnglish
Pages (from-to)1507-1510
Number of pages4
JournalJournal of Pediatrics
Volume163
Issue number5
DOIs
StatePublished - Nov 2013

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