Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein(Front. Immunol., (2024), 15, (1345473), 10.3389/fimmu.2024.1345473)

Mark A. Kroenke, Marta Starcevic Manning, Christina L. Zuch de Zafra, Xinwen Zhang, Kevin D. Cook, Michael Archer, Martijn P. Lolkema, Jin Wang, Sarah Hoofring, Gurleen Saini, Famke Aeffner, Elizabeth Ahern, Elena Garralda Cabanas, Ramaswamy Govindan, Mun Hui, Shalini Gupta, Daniel T. Mytych

Research output: Contribution to journalComment/debate

Abstract

In the published article, there was an error in Figure 2A as published. The Figure 2A y-axis should read “Serum concentration (ng/mL)”. The corrected Figure 2 is attached. IL-21 mutein domain enhanced the antibody response to 22D4 in cynomolgus monkeys. Cynomolgus monkeys were dosed with 5 mg/kg AMG 256, 5 mg/kg 22D4, or 5 mg/kg 22D4 plus 0.1 mg/kg recombinant human IL-21. (A) AMG 256 or 22D4 serum levels were measured over time in each of the 3 treatment groups. (B) The ADA response in each dosing group was assessed on day 15 and day 25 by UNISA. (C) Domain characterization was performed on AMG 256 dosed animals at the day 25 time point. Serum samples were pre-treated with either AMG 256 or 22D4 and re-tested in the antibody assay. Percent depletion indicates the signal change from the pre-treated sample relative to the untreated sample. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Original languageEnglish
Article number1441999
JournalFrontiers in immunology
Volume15
DOIs
StatePublished - 2024

Keywords

  • anti-drug antibodies
  • IgE
  • IL-21
  • immunogenicity
  • mutein
  • PD-1

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