Corrigendum to ‘OVATION-2: A randomized phase I/II study evaluating the safety and efficacy of IMNN-001 (IL-12 gene therapy) with neo/adjuvant chemotherapy in patients newly-diagnosed with advanced epithelial ovarian cancer’ [Gynecol Oncol 2025 Jun 197 182–191] (Gynecologic Oncology (2025) 197 (182–191), (S0090825825007978), (10.1016/j.ygyno.2025.04.578))

  • Premal Thaker
  • , Debra L. Richardson
  • , Andrea R. Hagemann
  • , Robert W. Holloway
  • , Mark Reed
  • , Melanie K. Bergman
  • , Bhavana Pothuri
  • , Stephen DePasquale
  • , Jennifer M. Scalici
  • , Amy J. Bregar
  • , Christopher J. Darus
  • , Karen Finkelstein
  • , Charles A. Leath
  • , Maria Bell
  • , David P. Warshal
  • , Richy Agajanian
  • , Megan D. Indermaur
  • , Alberto A. Mendivil
  • , Diane M. Provencher
  • , Lee Jen Wei
  • Nicholas Borys, Lauren Musso, Stacy R. Lindborg, Douglas V. Faller, Khursheed Anwer, William H. Bradley

Research output: Contribution to journalComment/debate

Abstract

The authors regret that it has come to our attention that our report contains an error as a result of an incorrect statistical analysis of a secondary endpoint at one of the timepoints of data analysis. Specifically, the OS data taken at the 31-month timepoint was not censored correctly. Nonetheless, the absolute OS benefit of the experimental arm over the control arm at this timepoint (13-month numerical increase in survival for the ITT population, and the respective improvements in survival for the subpopulations) is unchanged, and all of the conclusions in the paper remain correct and unchanged. Specifically: - Median OS for the ITT population at the 31-month analysis point should 40.5 mo vs 27.6 mo; HR 0.70, 95 % CI: 0.41–1.20). These data are cited in the paper in section 3.4, paragraph 1 and in the Results section of the Abstract. The survival benefit (13 months) remains correct and unchanged.- Median OS for the PARPi-treated population at the 31-month analysis point should be NE vs 37.1 mo with a HR of 0.42 (CI:0.15–1.17). These data are cited in the paper in section 3.4, paragraph 2; section 4, paragraph 7; and in the Results section of the Abstract. The survival benefit for this subpopulation remains correct and unchanged.- Median OS for the BRCA+/HRD population at the 31-month analysis point should be NE vs NE, (HR:0.55,95 %CI:0.15–1.97), These data are cited in the paper in section 3.4, paragraph 2; and section 4, paragraph 7. The survival benefit for this subpopulation remains correct and unchanged.Reflecting these corrections: - the Kaplan Meier plot shown in Fig. 2 and in the Graphical Abstract should be replaced with: [Figure presented] the Kaplan Meier plot shown in Fig. 3B should be replaced with:[Figure presented] The authors sincerely regret these discrepancies and are grateful for the opportunity to correct them. We also note again that the numerical OS benefits seen in the treatment arm remain unchanged, and continue to fully support the conclusions of the paper.

Original languageEnglish
Pages (from-to)182-183
Number of pages2
JournalGynecologic oncology
Volume203
DOIs
StatePublished - Dec 2025

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