Correlative Imaging in Neuroendocrine Tumors

Ameya Puranik, Sonal Prasad, Indraja D. Devi, Vikas Prasad

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Neuroendocrine tumors (NETs) are a large group of heterogeneous tumors arising from enterochromaffin cells of neural crest origin. NETs are broadly classified as functional and nonfunctional as many of these tumors have an ability to produce and secrete peptide hormones and biogenic amines, which in turn are responsible for their clinical manifestations. As NETs are hypervascular tumors, they are intensely enhanced on contrast-enhanced computed tomography (CT) scans. Magnetic resonance imaging has better sensitivity than conventional contrast-enhanced CT in the evaluation of liver metastases from NETs. Functional imaging utilizes various compounds tagged with another radioactive compound, which emits radiation, in turn captured by either a gamma camera or a positron emission tomography (PET) machine. Radiopharmaceuticals are indispensable tools for molecular imaging of NETs. The role of 18F-DOPA PET in the staging of well differentiated grade 1 and grade 2 NET is limited.

Original languageEnglish
Title of host publicationRadiology-Nuclear Medicine Diagnostic Imaging
Subtitle of host publicationA Correlative Approach
Number of pages9
ISBN (Electronic)9781119603627
ISBN (Print)9781119603610
StatePublished - Jan 1 2023


  • Computed tomography
  • Functional imaging
  • Gamma camera
  • Hypervascular tumors
  • Magnetic resonance imaging
  • Neuroendocrine tumors
  • Positron emission tomography
  • Radiopharmaceuticals


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