Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla

Denise A. Dorsey; Robert E. Schmidt

doi:10.1016/0304-3940(93)90552-V

Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla

Denise A. Dorsey, Robert E. Schmidt

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Abstract

The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.

Original language	English
Pages (from-to)	29-33
Number of pages	5
Journal	Neuroscience Letters
Volume	162
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(93)90552-V
State	Published - Nov 12 1993

Keywords

Adrenal medulla
Age
Diabetes
Growth-associated protein-43
Neuropeptide Y
Phenylethanolamine N-methyl transferase
Synaptic plasticity

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10.1016/0304-3940(93)90552-V

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title = "Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla",

abstract = "The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.",

keywords = "Adrenal medulla, Age, Diabetes, Growth-associated protein-43, Neuropeptide Y, Phenylethanolamine N-methyl transferase, Synaptic plasticity",

author = "Dorsey, {Denise A.} and Schmidt, {Robert E.}",

note = "Funding Information: This work was supported by NIH Grants DK19645 and AG10299. We would like to thank M. Willard for providing the antisera to GAP-43.",

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doi = "10.1016/0304-3940(93)90552-V",

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T1 - Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla

AU - Dorsey, Denise A.

AU - Schmidt, Robert E.

N1 - Funding Information: This work was supported by NIH Grants DK19645 and AG10299. We would like to thank M. Willard for providing the antisera to GAP-43.

PY - 1993/11/12

Y1 - 1993/11/12

N2 - The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.

AB - The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.

KW - Adrenal medulla

KW - Age

KW - Diabetes

KW - Growth-associated protein-43

KW - Neuropeptide Y

KW - Phenylethanolamine N-methyl transferase

KW - Synaptic plasticity

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VL - 162

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla

Abstract

Keywords

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