Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla

Denise A. Dorsey, Robert E. Schmidt

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalNeuroscience Letters
Volume162
Issue number1-2
DOIs
StatePublished - Nov 12 1993

Keywords

  • Adrenal medulla
  • Age
  • Diabetes
  • Growth-associated protein-43
  • Neuropeptide Y
  • Phenylethanolamine N-methyl transferase
  • Synaptic plasticity

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