Correlation of changes in oxygenation, lung water and hemodynamics after oleic acid-induced acute lung injury in dogs

D. P. Schuster, E. P. Trulock

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Changes in oxygenation after oleic acid (OA)-induced acute lung injury were correlated to changes in extravascular lung water (EVLW) and hemodynamics in 19 mongrel dogs. Three patterns seemed apparent. In group 1 (seven dogs) EVLW increased by 88% from control values but Pa(O2) fell only 15%. The change in Pa(O2) in this group was related directly to the change in mixed venous O2 tension (P(V̄O2)) after the OA-induced fall in cardiac output. In group 2 (eight dogs), EVLW rose by 120% and PaO2) fell 53%, 90 min after OA administration. In this group, there was a subsequent spontaneous improvement of Pa(O2) to 75% of control values, without any measured change in EVLW. In group 3 (four dogs), the fall in Pa(O2) was comparable to that of group 2, but the increase in EVLW was greater (148%) and there was no spontaneous improvement in oxygenation. Cardiac index fell in all three groups. A small but significant increase in P(V̄O2) partially explains the improvement in oxygenation in group 2. We conclude that changes in oxygenation are a poor index of injury during this model of acute lung injury and that the course of oxygenation is directly related to measured changes in EVLW and hemodynamics.

Original languageEnglish
Pages (from-to)1044-1048
Number of pages5
JournalCritical care medicine
Volume12
Issue number12
DOIs
StatePublished - Jan 1 1984

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