TY - JOUR
T1 - Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene
T2 - Evidence for assortative mating
AU - Nopoulos, Peg
AU - Epping, Eric A.
AU - Wassink, Tom
AU - Schlaggar, Bradley L.
AU - Perlmutter, Joel
N1 - Funding Information:
This work supported by a grant from the National Institutes for Neurologic Disorders and Stroke (NINDS), 5R01NS055903-03, and the CHDI Foundation.
PY - 2011/10/18
Y1 - 2011/10/18
N2 - Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.
AB - Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.
UR - http://www.scopus.com/inward/record.url?scp=80054091898&partnerID=8YFLogxK
U2 - 10.1186/1744-9081-7-45
DO - 10.1186/1744-9081-7-45
M3 - Article
C2 - 22008211
AN - SCOPUS:80054091898
SN - 1744-9081
VL - 7
JO - Behavioral and Brain Functions
JF - Behavioral and Brain Functions
M1 - 45
ER -