TY - JOUR
T1 - Correlation between Subfoveal Choroidal Thickness and Anterior Segment Inflammation in Patients with Chronic Stage of Vogt-Koyanagi-Harada Disease
AU - Ormaechea, Maria Soledad
AU - Hassan, Muhammad
AU - Mahajan, Sarakshi
AU - Nguyen, Quan Dong
AU - Couto, Cristobal
AU - Schlaen, Ariel
N1 - Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Purpose: To correlate changes in subfoveal choroidal thickness (SCT) with the degree of anterior inflammatory activity in chronic Vogt-Koyanagi-Harada (VKH) disease. Methods: Anterior segment inflammation was assessed using SUN anterior chamber cell grading criteria, and SCT was measured using EDI-OCT in patients with VKH at multiple visits. ANOVA was used to compare the mean SCT for each anterior chamber cell grade. Regression analysis was used to correlate the anterior segment cell grade and the SCT. Results: 14 patients were included in the study. A total of 432 data points consisting of SCT and anterior segment cell values were analyzed. ANOVA demonstrated significant difference between the mean SCT for different anterior chamber cell grades (p < .0001). Regression analysis demonstrated significant correlation between SCT and grade of anterior chamber cells (R2 = 0.37, p < .001). Conclusions: Chronic VKH is characterized by a dynamic change in SCT that correlates with anterior segment inflammatory activity.
AB - Purpose: To correlate changes in subfoveal choroidal thickness (SCT) with the degree of anterior inflammatory activity in chronic Vogt-Koyanagi-Harada (VKH) disease. Methods: Anterior segment inflammation was assessed using SUN anterior chamber cell grading criteria, and SCT was measured using EDI-OCT in patients with VKH at multiple visits. ANOVA was used to compare the mean SCT for each anterior chamber cell grade. Regression analysis was used to correlate the anterior segment cell grade and the SCT. Results: 14 patients were included in the study. A total of 432 data points consisting of SCT and anterior segment cell values were analyzed. ANOVA demonstrated significant difference between the mean SCT for different anterior chamber cell grades (p < .0001). Regression analysis demonstrated significant correlation between SCT and grade of anterior chamber cells (R2 = 0.37, p < .001). Conclusions: Chronic VKH is characterized by a dynamic change in SCT that correlates with anterior segment inflammatory activity.
KW - EDI-OCT
KW - Vogt Koyanagi Harada Disease
KW - anterior segment inflammation
KW - subfoveal choroidal thickness
KW - uveitis
UR - http://www.scopus.com/inward/record.url?scp=85092187911&partnerID=8YFLogxK
U2 - 10.1080/09273948.2020.1826533
DO - 10.1080/09273948.2020.1826533
M3 - Article
C2 - 33021859
AN - SCOPUS:85092187911
SN - 0927-3948
VL - 30
SP - 646
EP - 651
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 3
ER -