TY - JOUR
T1 - Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism
T2 - In Vivo Studies in Man
AU - Raichle, Marcus E.
AU - Grubb, Robert L.
AU - Gado, Mokhtar H.
AU - Eichling, John O.
AU - Ter-Pogossian, Michel M.
PY - 1976/8
Y1 - 1976/8
N2 - To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO2) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO2. In one individual with mild dementia, rCBF and rCMRO2 were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate parallel changes occurred in both rCBF and rCMRO2 during hand exercise. In patients with acute diseases affecting the hemisphere studied, however, the correlation between rCBF and rCMRO2 was unpredictable.
AB - To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO2) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO2. In one individual with mild dementia, rCBF and rCMRO2 were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate parallel changes occurred in both rCBF and rCMRO2 during hand exercise. In patients with acute diseases affecting the hemisphere studied, however, the correlation between rCBF and rCMRO2 was unpredictable.
UR - http://www.scopus.com/inward/record.url?scp=0017076346&partnerID=8YFLogxK
U2 - 10.1001/archneur.1976.00500080001001
DO - 10.1001/archneur.1976.00500080001001
M3 - Article
C2 - 942309
AN - SCOPUS:0017076346
VL - 33
SP - 523
EP - 526
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 8
ER -