Correlation between colposcopically directed biopsy and cervical loop excision

L. Stewart Massad, Cathy J. Halperin, Pincas Bitterman

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Colposcopy is standard for diagnosis of cervical cancer precursors, but the development of diathermy loop electrodes for excision of the cervical transformation zone offers a technique for validation. Loop excision of the transformation zone was performed for 47 consecutive women with dysplasia in colposcopically directed biopsies using 20 x 8-mm electrodes. Specimens were marked for orientation and serially sectioned. All pathology material was reviewed. Although 28% of women had disappearance of dysplasia at the biopsy site, only 9% had no dysplasia in the transformation zone. Half of the women with CIN 1 on directed biopsy had highgrade lesions found in loop excision specimens. Significant discrepancies may be found between the results of colposcopically directed biopsy and loop excision.

Original languageEnglish
Pages (from-to)400-403
Number of pages4
JournalGynecologic oncology
Issue number3
StatePublished - Mar 1996


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