Background Blood pressure (BP) responses to dietary sodium and potassium intake vary among individuals. We examined the correlation between BP responses to dietary low-sodium, high-sodium, and potassium supplementation interventions in a feeding study.MethodsA total of 1,906 Chinese aged 16 years participated in the dietary intervention that included a 7-day low-salt intervention (51.3 mmol/day), a 7-day high-salt intervention (307.8 mmol/day), and a 7-day high-salt plus potassium supplementation (60 mmol/day) intervention. BP was measured nine times during the 3-day baseline observation and during the last 3 days of each intervention phase using a random-zero sphygmomanometer.ResultsThe correlation coefficients (95% confidence intervals (CIs)) of the BP responses to low-sodium and high-sodium interventions were 0.47 (0.51 to 0.44), 0.47 (0.50 to 0.43), and 0.45 (0.49 to 0.42) for systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP), respectively (all P 0.0001). The correlation coefficients (95% CI) of the BP responses to high-sodium intervention and potassium supplementation were 0.52 (0.56 to 0.49), 0.48 (0.52 to 0.45), and 0.52 (0.55 to 0.48) for SBP, DBP, and MAP, respectively (all P 0.0001). The coefficients were moderate, varying from 0.28 to 0.34, between BP responses to low-sodium and high-sodium interventions (all P 0.0001).ConclusionsThese results indicate there is a moderate correlation between BP responses to low-sodium and to high-sodium interventions, and BP responses to high-sodium intervention and potassium supplementation. Furthermore, our study suggests that individuals who were more sensitive to high-sodium diet might benefit more from a low-sodium and/or high-potassium intervention aimed at lowering BP levels.