TY - JOUR
T1 - Correlation between blood pressure responses to dietary sodium and potassium intervention in a Chinese population
AU - Zhao, Qi
AU - Gu, Dongfeng
AU - Chen, Jing
AU - Bazzano, Lydia A.
AU - Rao, Dabeeru C.
AU - Hixson, James E.
AU - Jaquish, Cashell E.
AU - Cao, Jie
AU - Chen, Jichun
AU - Li, Jianxin
AU - Rice, Treva
AU - He, Jiang
N1 - Funding Information:
Acknowledgments: The Genetic Epidemiology Network of Salt Sensitivity is supported by research grants (U01HL072507, R01HL087263, and R01HL090682) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Upsher-Smith Laboratories, Maple Grove, MN has provided Klor-con M20 potassium tablets for the GenSalt study. L.A.B. was supported by a career development grant (K08HL091108) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
PY - 2009/12
Y1 - 2009/12
N2 - Background Blood pressure (BP) responses to dietary sodium and potassium intake vary among individuals. We examined the correlation between BP responses to dietary low-sodium, high-sodium, and potassium supplementation interventions in a feeding study.MethodsA total of 1,906 Chinese aged 16 years participated in the dietary intervention that included a 7-day low-salt intervention (51.3 mmol/day), a 7-day high-salt intervention (307.8 mmol/day), and a 7-day high-salt plus potassium supplementation (60 mmol/day) intervention. BP was measured nine times during the 3-day baseline observation and during the last 3 days of each intervention phase using a random-zero sphygmomanometer.ResultsThe correlation coefficients (95% confidence intervals (CIs)) of the BP responses to low-sodium and high-sodium interventions were 0.47 (0.51 to 0.44), 0.47 (0.50 to 0.43), and 0.45 (0.49 to 0.42) for systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP), respectively (all P 0.0001). The correlation coefficients (95% CI) of the BP responses to high-sodium intervention and potassium supplementation were 0.52 (0.56 to 0.49), 0.48 (0.52 to 0.45), and 0.52 (0.55 to 0.48) for SBP, DBP, and MAP, respectively (all P 0.0001). The coefficients were moderate, varying from 0.28 to 0.34, between BP responses to low-sodium and high-sodium interventions (all P 0.0001).ConclusionsThese results indicate there is a moderate correlation between BP responses to low-sodium and to high-sodium interventions, and BP responses to high-sodium intervention and potassium supplementation. Furthermore, our study suggests that individuals who were more sensitive to high-sodium diet might benefit more from a low-sodium and/or high-potassium intervention aimed at lowering BP levels.
AB - Background Blood pressure (BP) responses to dietary sodium and potassium intake vary among individuals. We examined the correlation between BP responses to dietary low-sodium, high-sodium, and potassium supplementation interventions in a feeding study.MethodsA total of 1,906 Chinese aged 16 years participated in the dietary intervention that included a 7-day low-salt intervention (51.3 mmol/day), a 7-day high-salt intervention (307.8 mmol/day), and a 7-day high-salt plus potassium supplementation (60 mmol/day) intervention. BP was measured nine times during the 3-day baseline observation and during the last 3 days of each intervention phase using a random-zero sphygmomanometer.ResultsThe correlation coefficients (95% confidence intervals (CIs)) of the BP responses to low-sodium and high-sodium interventions were 0.47 (0.51 to 0.44), 0.47 (0.50 to 0.43), and 0.45 (0.49 to 0.42) for systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP), respectively (all P 0.0001). The correlation coefficients (95% CI) of the BP responses to high-sodium intervention and potassium supplementation were 0.52 (0.56 to 0.49), 0.48 (0.52 to 0.45), and 0.52 (0.55 to 0.48) for SBP, DBP, and MAP, respectively (all P 0.0001). The coefficients were moderate, varying from 0.28 to 0.34, between BP responses to low-sodium and high-sodium interventions (all P 0.0001).ConclusionsThese results indicate there is a moderate correlation between BP responses to low-sodium and to high-sodium interventions, and BP responses to high-sodium intervention and potassium supplementation. Furthermore, our study suggests that individuals who were more sensitive to high-sodium diet might benefit more from a low-sodium and/or high-potassium intervention aimed at lowering BP levels.
UR - http://www.scopus.com/inward/record.url?scp=70450222729&partnerID=8YFLogxK
U2 - 10.1038/ajh.2009.176
DO - 10.1038/ajh.2009.176
M3 - Article
C2 - 19763120
AN - SCOPUS:70450222729
SN - 0895-7061
VL - 22
SP - 1281
EP - 1286
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 12
ER -