TY - JOUR
T1 - Correlating papanicolaou smear, colposcopic impression, and biopsy
T2 - Results from the women's interagency HIV study
AU - Massad, L. Stewart
AU - Schneider, Michael
AU - Watts, Heather
AU - Darragh, Teresa
PY - 2001
Y1 - 2001
N2 - Objective. To determine associations among cervical cytology, colposcopy, and biopsy in HIV-seropositive women. Materials and methods. HIV-seropositive women and uninfected comparison women in a multicenter prospective cohort study underwent colposcopy for protocol indications. Women were eligible if they had a cervix, satisfactory cytology, and colposcopy between October 1994 and September 1999. Cytology, colposcopic impression, and biopsy were compared using equivalent categorizations. Kappa statistics with bootstrap sampling assessed strength of associations. Results. Colposcopy was performed in 978/1370 HIV-seropositive women and in 154/224 seronegative women. Biopsies were performed on 603 (44%) seropositive women at least once during 1015 colposcopy visits and on 82 (37%) seronegative women at 116 visits. The positive predictive value of cytology was 72% for seropositive women and 60% for seronegative women. The positive predictive value of colposcopy was 71% for seropositive women and 55% for seronegative women. Conclusion. The correlation between either cervical cytology or colposcopic impression and colposcopic biopsy was poor.
AB - Objective. To determine associations among cervical cytology, colposcopy, and biopsy in HIV-seropositive women. Materials and methods. HIV-seropositive women and uninfected comparison women in a multicenter prospective cohort study underwent colposcopy for protocol indications. Women were eligible if they had a cervix, satisfactory cytology, and colposcopy between October 1994 and September 1999. Cytology, colposcopic impression, and biopsy were compared using equivalent categorizations. Kappa statistics with bootstrap sampling assessed strength of associations. Results. Colposcopy was performed in 978/1370 HIV-seropositive women and in 154/224 seronegative women. Biopsies were performed on 603 (44%) seropositive women at least once during 1015 colposcopy visits and on 82 (37%) seronegative women at 116 visits. The positive predictive value of cytology was 72% for seropositive women and 60% for seronegative women. The positive predictive value of colposcopy was 71% for seropositive women and 55% for seronegative women. Conclusion. The correlation between either cervical cytology or colposcopic impression and colposcopic biopsy was poor.
KW - Cervical cytology
KW - Colposcopy
KW - HIV
UR - http://www.scopus.com/inward/record.url?scp=0035697128&partnerID=8YFLogxK
U2 - 10.1046/j.1526-0976.2001.54005.x
DO - 10.1046/j.1526-0976.2001.54005.x
M3 - Article
AN - SCOPUS:0035697128
VL - 5
SP - 212
EP - 218
JO - Journal of Lower Genital Tract Disease
JF - Journal of Lower Genital Tract Disease
SN - 1089-2591
IS - 4
ER -