Correlating papanicolaou smear, colposcopic impression, and biopsy: Results from the women's interagency HIV study

L. Stewart Massad, Michael Schneider, Heather Watts, Teresa Darragh

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Objective. To determine associations among cervical cytology, colposcopy, and biopsy in HIV-seropositive women. Materials and methods. HIV-seropositive women and uninfected comparison women in a multicenter prospective cohort study underwent colposcopy for protocol indications. Women were eligible if they had a cervix, satisfactory cytology, and colposcopy between October 1994 and September 1999. Cytology, colposcopic impression, and biopsy were compared using equivalent categorizations. Kappa statistics with bootstrap sampling assessed strength of associations. Results. Colposcopy was performed in 978/1370 HIV-seropositive women and in 154/224 seronegative women. Biopsies were performed on 603 (44%) seropositive women at least once during 1015 colposcopy visits and on 82 (37%) seronegative women at 116 visits. The positive predictive value of cytology was 72% for seropositive women and 60% for seronegative women. The positive predictive value of colposcopy was 71% for seropositive women and 55% for seronegative women. Conclusion. The correlation between either cervical cytology or colposcopic impression and colposcopic biopsy was poor.

Original languageEnglish
Pages (from-to)212-218
Number of pages7
JournalJournal of lower genital tract disease
Volume5
Issue number4
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Cervical cytology
  • Colposcopy
  • HIV

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