TY - JOUR
T1 - Correction of positron emission tomography data for cerebral atrophy
AU - Herscovitch, P.
AU - Auchus, A. P.
AU - Gado, M.
AU - Chi, D.
AU - Raichle, M. E.
PY - 1986
Y1 - 1986
N2 - Because positron emission tomography (PET) provides measurements per unit volume of intracranial contens, these measurements may be affected by the inclusion of metabolically inactive CSF spaces in the volume in which they are made. Thus, PET measurements of CBF and metabolism may be artifactually lowered in normal aging and dementia, which are both associated with significant brain atrophy. We describe a method to correct global PET data, averaged over several tomographic slices, for cerebral atrophy by using measurements of CSF space volume obtained with quantitative x-ray computed tomography. The importance of making such a correction is demonstrated using PET measurements of CBF and oxygen metabolism obtained in normal young, normal elderly, and demented subjects.
AB - Because positron emission tomography (PET) provides measurements per unit volume of intracranial contens, these measurements may be affected by the inclusion of metabolically inactive CSF spaces in the volume in which they are made. Thus, PET measurements of CBF and metabolism may be artifactually lowered in normal aging and dementia, which are both associated with significant brain atrophy. We describe a method to correct global PET data, averaged over several tomographic slices, for cerebral atrophy by using measurements of CSF space volume obtained with quantitative x-ray computed tomography. The importance of making such a correction is demonstrated using PET measurements of CBF and oxygen metabolism obtained in normal young, normal elderly, and demented subjects.
UR - http://www.scopus.com/inward/record.url?scp=0022593264&partnerID=8YFLogxK
U2 - 10.1038/jcbfm.1986.14
DO - 10.1038/jcbfm.1986.14
M3 - Article
C2 - 3484745
AN - SCOPUS:0022593264
SN - 0271-678X
VL - 6
SP - 120
EP - 124
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 1
ER -