Correction: Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts (doi:10.1242/jcs.180539) (J. Cell Sci. (2016) 129, (1989-2002) DOI:10.1242/jcs.180539)

Kun Zhang, Whitney R. Grither, Samantha Van Hove, Hirak Biswas, Suzanne M. Ponik, Kevin W. Eliceiri, Patricia J. Keely, Gregory D. Longmore

Research output: Contribution to journalComment/debate

Abstract

The -YAP panels on stiff substrate in Fig. 8C were incorrectly duplicated in Fig. 6A. The journal has seen the original data for Fig. 6A and the corrected and original panels are shown below. This error does not affect the results or conclusions. The online full-text and PDF versions of the paper have been updated. Fig. 6 (corrected panel). ROCK increases SNAIL1 nuclear accumulation through activation of ERK2. (A) Immunofluorescent staining for SNAIL1 (green), F-actin (Rhodamine–phalloidin, red) and nuclei (DAPI, blue) in CAFs cultured on fibronectin-coated soft (80–120 Pa) or stiff (120 kPa) hydrogels for 12 h that were treated with scrambled shRNA (CTL) or depleted of ERK2 with shRNA (–ERK2). Histogram on right quantifies the nuclear-to-cytosolic fluorescent intensity ratio of SNAIL1 using ImageJ software. Bars represent the mean±s.d.; more than 50 cells, in multiple fields were scored. *P<0.05 (unpaired, two-tailed Student’s t-tests). Scale bars: 20 µm. Fig. 6 (original panel). ROCK increases SNAIL1 nuclear accumulation through activation of ERK2. (A) Immunofluorescent staining for SNAIL1 (green), F-actin (Rhodamine–phalloidin, red) and nuclei (DAPI, blue) in CAFs cultured on fibronectin-coated soft (80–120 Pa) or stiff (120 kPa) hydrogels for 12 h that were treated with scrambled shRNA (CTL) or depleted of ERK2 with shRNA (–ERK2). Histogram on right quantifies the nuclear-to-cytosolic fluorescent intensity ratio of SNAIL1 using ImageJ software. Bars represent the mean±s.d.; more than 50 cells, in multiple fields were scored. *P<0.05 (unpaired, two-tailed Student’s t-tests). Scale bars: 20 µm.

Original languageEnglish
Article numberjcs232348
JournalJournal of cell science
Volume132
Issue number9
DOIs
StatePublished - May 1 2019

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