Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase

G. F. Wu, L. Pewe, S. Perlman

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Demyelination induced by mouse hepatitis virus (MHV), strain JHM, is in large part immune mediated, but little is known about the mechanisms involved in this process. Previous results suggest that inducible nitric oxide synthase (NOS2) contributes transiently to MHV-induced demyelination. Herein, we show that equivalent amounts of demyelination were evident at day 12 after MHV infection in mice genetically deficient in NOS2 (NOS2(-/-)) and in C57BL/6 mice. Furthermore, using an established adoptive transfer model and pharmacological inhibitors of NOS2 function, we could demonstrate no effect on MHV-induced demyelination. These results indicate that NOS2 function is not required for demyelination in mice infected with MHV.

Original languageEnglish
Pages (from-to)7683-7686
Number of pages4
JournalJournal of virology
Volume74
Issue number16
DOIs
StatePublished - Aug 21 2000
Externally publishedYes

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