TY - JOUR
T1 - Coronary vessel development
T2 - The epicardium delivers
AU - Olivey, Harold E.
AU - Compton, Leigh A.
AU - Barnett, Joey V.
N1 - Funding Information:
The authors have attempted to distill the major ideas and discoveries that have shaped this area. Inevitably, owing to limited space, some insights have not been discussed and some references have been omitted. They apologize for this and encourage the reader to explore the area fully. J.V.B. wishes to acknowledge the support of HL67105, HL52922, the March of Dimes, and the American Heart Association. The authors thank Drs. Jorg Manner and Patrick Nahirney for supplying figures and Drs. David Bader and Christopher Brown for critically reading the manuscript.
PY - 2004/8
Y1 - 2004/8
N2 - Coronary artery disease accounts for 54% of all cardiovascular disease in the United States. Understanding how coronary vessels develop is likely to uncover novel drug targets and therapeutic strategies that will be useful in directing the repair or remodeling of coronary vessels in adults. Recent insights have identified the importance of cells derived from the proepicardium and epicardium in the formation of coronary vessels. This article reviews the basic steps in coronary vessel development, the molecules implicated in these steps, and the pressing questions awaiting answers.
AB - Coronary artery disease accounts for 54% of all cardiovascular disease in the United States. Understanding how coronary vessels develop is likely to uncover novel drug targets and therapeutic strategies that will be useful in directing the repair or remodeling of coronary vessels in adults. Recent insights have identified the importance of cells derived from the proepicardium and epicardium in the formation of coronary vessels. This article reviews the basic steps in coronary vessel development, the molecules implicated in these steps, and the pressing questions awaiting answers.
UR - http://www.scopus.com/inward/record.url?scp=4644313812&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2004.07.001
DO - 10.1016/j.tcm.2004.07.001
M3 - Review article
C2 - 15451517
AN - SCOPUS:4644313812
SN - 1050-1738
VL - 14
SP - 247
EP - 251
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 6
ER -