Coronary microvascular dysfunction, left ventricular remodeling, and clinical outcomes in aortic stenosis

Wunan Zhou, Navkranbir Bajaj, Ankur Gupta, Yee Ping Sun, Sanjay Divakaran, Courtney Bibbo, Jon Hainer, Viviany Taqueti, Sharmila Dorbala, Ron Blankstein, Pinak Shah, Tsuyoshi Kaneko, Dale Adler, Patrick O’Gara, Marcelo Di Carli

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: We investigated role of coronary microvascular disease (CMD) in maladaptive LV remodeling and prognosis in patients with aortic sclerosis or stenosis and no overt CAD. Methods: This was a retrospective cohort study of patients with aortic sclerosis or stenosis, normal myocardial perfusion and LV ejection fraction (EF) > 50% (n = 43) and matched controls without AS (n = 43). PET and echocardiograms were performed within 1 year of each other. Myocardial perfusion and myocardial flow reserve (MFR) were quantified using PET imaging. LV structure and function, including global longitudinal strain (GLS), were quantified by transthoracic echocardiography. Results: Global MFR declined with increasing AS severity (P = 0.04). Probability of impaired MFR increased with severity of adverse LV remodeling (OR 1.88, CI 1.03 to 3.41, P =0.04). Reduced MFR associated with impaired GLS (r = − 0.29, P = 0.002) and associated with reduced MACE-free survival at 7.27 years median follow-up. Adjusted annualized rate of MACE was highest in those with impaired GLS and MFR and lowest in those with normal GLS and MFR (30.99% vs 1.86%, P =0.002). Conclusion and Relevance: In patients with AS and no overt CAD, impaired MFR associates with adverse LV remodeling and subclinical LV mechanical dysfunction, and is a marker increased clinical risk.

Original languageEnglish
Pages (from-to)579-588
Number of pages10
JournalJournal of Nuclear Cardiology
Issue number2
StatePublished - Apr 2021


  • PET
  • echo
  • modalities
  • myocardial blood flow
  • tests


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