Coronary capillary permeability and tissue volumes for sucrose and water in dogs: A comparison of bolus and constant infusion multiple-indicator methods

Thomas R. Harris; Deland D. Burks; Phillip L. Custer

doi:10.1093/cvr/12.9.537

Coronary capillary permeability and tissue volumes for sucrose and water in dogs: A comparison of bolus and constant infusion multiple-indicator methods

Thomas R. Harris
, Deland D. Burks
, Phillip L. Custer

Department of Ophthalmology and Visual Sciences

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Summary: This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26± 0.02 cm³·(min.g tissue)^-1. The extravascular sucrose volume averaged 0.15 cm³·g^-1 tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85% of the post-mortem water content.

Original language	English
Pages (from-to)	537-546
Number of pages	10
Journal	Cardiovascular Research
Volume	12
Issue number	9
DOIs	https://doi.org/10.1093/cvr/12.9.537
State	Published - Sep 1978

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@article{4eced465b3374fa1838a5d64d66b253e,

title = "Coronary capillary permeability and tissue volumes for sucrose and water in dogs: A comparison of bolus and constant infusion multiple-indicator methods",

abstract = "Summary: This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26± 0.02 cm3·(min.g tissue)-1. The extravascular sucrose volume averaged 0.15 cm3·g-1 tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85\% of the post-mortem water content.",

author = "Harris, \{Thomas R.\} and Burks, \{Deland D.\} and Custer, \{Phillip L.\}",

note = "Funding Information: Supported by National Heart and Lung Institute Grant HL 19370-01, the Middle Tennessee Heart Association and the Hugh J. Morgan Fund for Cardiology, donated by Martha Washington Straus-Harry H. Straus Foundation.",

year = "1978",

month = sep,

doi = "10.1093/cvr/12.9.537",

language = "English",

volume = "12",

pages = "537--546",

journal = "Cardiovascular Research",

issn = "0008-6363",

number = "9",

}

TY - JOUR

T1 - Coronary capillary permeability and tissue volumes for sucrose and water in dogs

T2 - A comparison of bolus and constant infusion multiple-indicator methods

AU - Harris, Thomas R.

AU - Burks, Deland D.

AU - Custer, Phillip L.

N1 - Funding Information: Supported by National Heart and Lung Institute Grant HL 19370-01, the Middle Tennessee Heart Association and the Hugh J. Morgan Fund for Cardiology, donated by Martha Washington Straus-Harry H. Straus Foundation.

PY - 1978/9

Y1 - 1978/9

N2 - Summary: This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26± 0.02 cm3·(min.g tissue)-1. The extravascular sucrose volume averaged 0.15 cm3·g-1 tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85% of the post-mortem water content.

AB - Summary: This study was undertaken to determine the accuracy with which heart interstitial and water volumes could be determined from multiple-indicator dilution experiments on the coronary circulation in open-chest dog preparations. Sucrose permeability by extraction calculations was found to average 0.26± 0.02 cm3·(min.g tissue)-1. The extravascular sucrose volume averaged 0.15 cm3·g-1 tissue by both multiple-indicator and post-mortem methods. Indicator-dilution tritiated water curves labelled 85% of the post-mortem water content.

UR - https://www.scopus.com/pages/publications/0018231414

U2 - 10.1093/cvr/12.9.537

DO - 10.1093/cvr/12.9.537

M3 - Review article

C2 - 367598

AN - SCOPUS:0018231414

SN - 0008-6363

VL - 12

SP - 537

EP - 546

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 9

ER -

Coronary capillary permeability and tissue volumes for sucrose and water in dogs: A comparison of bolus and constant infusion multiple-indicator methods

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