TY - JOUR
T1 - Corneal keloid presenting forty years after penetrating injury
T2 - Case report and literature review
AU - Palko, Joel R.
AU - Arfeen, Safa
AU - Farooq, Asim V.
AU - Reppa, Catherine
AU - Harocopos, George J.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - A 64-year-old Caucasian man had been diagnosed with presumed ocular surface squamous neoplasia in the left eye and started on topical interferon alpha 2b drops. When we saw him, he provided a history of penetrating corneal injury more than forty years before. Slit lamp examination revealed a large, elevated, opaque lesion involving the left cornea. High-definition anterior segment optical coherence tomography revealed a hyperreflective lesion involving the anterior stroma with a relatively normal overlying epithelium. Based on the clinical history, slit lamp, and anterior segment optical coherence tomography findings, a giant corneal keloid was suspected, and the interferon drops were discontinued. He subsequently underwent a penetrating keratoplasty, and histopathologic analysis was consistent with corneal keloid. Corneal keloids may be seen decades after the initial trauma, and anterior segment optical coherence tomography can be a useful tool in differentiating these tumor-like lesions from other neoplasia.
AB - A 64-year-old Caucasian man had been diagnosed with presumed ocular surface squamous neoplasia in the left eye and started on topical interferon alpha 2b drops. When we saw him, he provided a history of penetrating corneal injury more than forty years before. Slit lamp examination revealed a large, elevated, opaque lesion involving the left cornea. High-definition anterior segment optical coherence tomography revealed a hyperreflective lesion involving the anterior stroma with a relatively normal overlying epithelium. Based on the clinical history, slit lamp, and anterior segment optical coherence tomography findings, a giant corneal keloid was suspected, and the interferon drops were discontinued. He subsequently underwent a penetrating keratoplasty, and histopathologic analysis was consistent with corneal keloid. Corneal keloids may be seen decades after the initial trauma, and anterior segment optical coherence tomography can be a useful tool in differentiating these tumor-like lesions from other neoplasia.
KW - anterior segment ocular coherence tomography
KW - cornea
KW - histopathology
KW - immunohistochemical staining
KW - keloid
KW - ocular surface squamous neoplasia
UR - http://www.scopus.com/inward/record.url?scp=85065138093&partnerID=8YFLogxK
U2 - 10.1016/j.survophthal.2019.02.010
DO - 10.1016/j.survophthal.2019.02.010
M3 - Review article
C2 - 30849427
AN - SCOPUS:85065138093
SN - 0039-6257
VL - 64
SP - 700
EP - 706
JO - Survey of ophthalmology
JF - Survey of ophthalmology
IS - 5
ER -