TY - JOUR
T1 - Coordinating mitosis with cell polarity
T2 - Molecular motors at the cell cortex
AU - Moore, Jeffrey K.
AU - Cooper, John A.
N1 - Funding Information:
The writing of this review and research in our lab on this topic was supported by NIH R01 GM47337 . We are grateful to Melissa D. Stuchell-Brereton for critical reading of this manuscript.
PY - 2010/5
Y1 - 2010/5
N2 - In many cell divisions, the position of the spindle apparatus is coordinated with polarity signals at the cell cortex so that copies of the genome are delivered to regions of the cell that are designated for differential inheritance by the two progeny. To coordinate spindle position with cell polarity, the spindle interfaces with elements on the cortex, where molecular motors often produce the forces that power displacement. Here we describe the molecular pathways by which cortical motors translocate the spindle in budding yeast, where the mechanisms are understood relatively well, and we compare these pathways to spindle positioning processes in metazoan systems, where the molecular details are less well understood.
AB - In many cell divisions, the position of the spindle apparatus is coordinated with polarity signals at the cell cortex so that copies of the genome are delivered to regions of the cell that are designated for differential inheritance by the two progeny. To coordinate spindle position with cell polarity, the spindle interfaces with elements on the cortex, where molecular motors often produce the forces that power displacement. Here we describe the molecular pathways by which cortical motors translocate the spindle in budding yeast, where the mechanisms are understood relatively well, and we compare these pathways to spindle positioning processes in metazoan systems, where the molecular details are less well understood.
KW - Cytoplasmic microtubules
KW - Dynein
KW - Kinesin
KW - Spindle
KW - myosin
UR - http://www.scopus.com/inward/record.url?scp=77949492372&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2010.01.020
DO - 10.1016/j.semcdb.2010.01.020
M3 - Review article
C2 - 20109571
AN - SCOPUS:77949492372
SN - 1084-9521
VL - 21
SP - 283
EP - 289
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
IS - 3
ER -