TY - JOUR
T1 - Convergence and extension in vertebrate gastrulae
T2 - Cell movements according to or in search of identity?
AU - Myers, Dina C.
AU - Sepich, Diane S.
AU - Solnica-Krezel, Lilianna
N1 - Funding Information:
We thank Bruce Appel, Toshio Hirano, John Wallingford and members of our laboratory for discussions and constructive comments on the manuscript. We also thank Toshio Hirano for contributing images for Fig. 4 i,j and Masa Tada for sharing results before publication. We apologize to the authors of original work not cited here because of space limitations. D.S. Sepich is supported by a Vascular Biology Training Grant T32HL07751. L. Solnica-Krezel acknowledges support from NIH, March of Dimes Birth Defects Foundation and Pew Scholars Program in Biomedical Sciences.
PY - 2002/9/1
Y1 - 2002/9/1
N2 - During vertebrate gastrulation, convergence and extension cell movements both narrow and lengthen the forming embryonic axis. Concurrently, positional information established principally by the ventral-to-dorsal gradient of bone morphogenetic protein activity specifies cell fates within the gastrula. New data, primarily from zebrafish, have identified domains of distinct convergence and extension movements, and have established a role for the noncanonical Wnt signaling pathway in promoting the mediolateral cell polarization that underlies this morphogenetic process. Other observations suggest the intriguing possibility that positional information regulates convergence and extension movements in parallel with cell-fate specification.
AB - During vertebrate gastrulation, convergence and extension cell movements both narrow and lengthen the forming embryonic axis. Concurrently, positional information established principally by the ventral-to-dorsal gradient of bone morphogenetic protein activity specifies cell fates within the gastrula. New data, primarily from zebrafish, have identified domains of distinct convergence and extension movements, and have established a role for the noncanonical Wnt signaling pathway in promoting the mediolateral cell polarization that underlies this morphogenetic process. Other observations suggest the intriguing possibility that positional information regulates convergence and extension movements in parallel with cell-fate specification.
UR - http://www.scopus.com/inward/record.url?scp=0036716748&partnerID=8YFLogxK
U2 - 10.1016/S0168-9525(02)02725-7
DO - 10.1016/S0168-9525(02)02725-7
M3 - Review article
C2 - 12175805
AN - SCOPUS:0036716748
SN - 0168-9525
VL - 18
SP - 447
EP - 455
JO - Trends in Genetics
JF - Trends in Genetics
IS - 9
ER -