Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Marlies Ostermann, Rinaldo Bellomo, Emmanuel A. Burdmann, Kent Doi, Zoltan H. Endre, Stuart L. Goldstein, Sandra L. Kane-Gill, Kathleen D. Liu, John R. Prowle, Andrew D. Shaw, Nattachai Srisawat, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, John A. Kellum, Sean M. Bagshaw, Erin F. Barreto, Azra Bihorac, Ilona Bobek, Josée BouchardJorge Cerdá, Rajasekara Chakravarthi, Silvia De Rosa, Daniel T. Engelman, Lui G. Forni, Ulla K. Hemmilä, Charles A. Herzog, Eric A. Hoste, Sarah C. Huen, Kunitoshi Iseki, Michael Joannidis, Kianoush B. Kashani, Jay L. Koyner, Andreas Kribben, Norbert Lameire, Andrew S. Levey, Etienne Macedo, Jolanta Małyszko, Melanie Meersch, Ravindra L. Mehta, Irene Mewburn, Olga Mironova, Patrick T. Murray, Mitra K. Nadim, Jenny S. Pan, Neesh Pannu, Zhiyong Peng, Barbara Philips, Daniela Ponce, Patricio E. Ray, Zaccaria Ricci, Thomas Rimmelé, Claudio Ronco, Edward D. Siew, Paul E. Stevens, Ashita J. Tolwani, Marcello Tonelli, Suvi T. Vaara, Marjel van Dam, Anitha Vijayan, Michael Wise, Vin Cent Wu, Alexander Zarbock

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In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available through February 2011. Since then, new evidence has emerged that has important implications for clinical practice in diagnosing and managing AKI. In April of 2019, KDIGO held a controversies conference entitled Acute Kidney Injury with the following goals: determine best practices and areas of uncertainty in treating AKI; review key relevant literature published since the 2012 KDIGO AKI guideline; address ongoing controversial issues; identify new topics or issues to be revisited for the next iteration of the KDIGO AKI guideline; and outline research needed to improve AKI management. Here, we present the findings of this conference and describe key areas that future guidelines may address.

Original languageEnglish
Pages (from-to)294-309
Number of pages16
JournalKidney International
Issue number2
StatePublished - Aug 2020


  • acute kidney disease
  • acute kidney injury
  • fluid management
  • nephrotoxicity
  • renal replacement therapy
  • risk stratification


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