Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

Farshid Guilak; Daniel M. Cohen; Bradley T. Estes; Jeffrey M. Gimble; Wolfgang Liedtke; Christopher S. Chen

doi:10.1016/j.stem.2009.06.016

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

Farshid Guilak, Daniel M. Cohen, Bradley T. Estes, Jeffrey M. Gimble, Wolfgang Liedtke, Christopher S. Chen

Research output: Contribution to journal › Review article › peer-review

1616 Scopus citations

Abstract

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

Original language	English
Pages (from-to)	17-26
Number of pages	10
Journal	Cell Stem Cell
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2009.06.016
State	Published - Jul 2 2009

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title = "Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix",

abstract = "A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.",

author = "Farshid Guilak and Cohen, {Daniel M.} and Estes, {Bradley T.} and Gimble, {Jeffrey M.} and Wolfgang Liedtke and Chen, {Christopher S.}",

note = "Funding Information: This study was supported in part by NIH grants AG15768, AR048852, AR48182, AR50245, GM74048, EB00262, and EB001046; the Coulter Foundation; and the Duke Translational Research Institute. ",

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AU - Estes, Bradley T.

AU - Gimble, Jeffrey M.

AU - Liedtke, Wolfgang

AU - Chen, Christopher S.

N1 - Funding Information: This study was supported in part by NIH grants AG15768, AR048852, AR48182, AR50245, GM74048, EB00262, and EB001046; the Coulter Foundation; and the Duke Translational Research Institute.

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Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

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