Control of lipolysis by a population of oxytocinergic sympathetic neurons

Erwei Li, Luhong Wang, Daqing Wang, Jingyi Chi, Zeran Lin, Gordon I. Smith, Samuel Klein, Paul Cohen, Evan D. Rosen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Oxytocin (OXT), a nine-amino-acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation and social behaviour 1, and has become an intriguing therapeutic target for conditions such as autism and schizophrenia 2. Exogenous OXT has also been shown to have effects on body weight, lipid levels and glucose homeostasis 1,3, suggesting that it may also have therapeutic potential for metabolic disease 1,4. It is unclear, however, whether endogenous OXT participates in metabolic homeostasis. Here we show that OXT is a critical regulator of adipose tissue lipolysis in both mice and humans. In addition, OXT serves to facilitate the ability of β-adrenergic agonists to fully promote lipolysis. Most surprisingly, the relevant source of OXT in these metabolic actions is a previously unidentified subpopulation of tyrosine hydroxylase-positive sympathetic neurons. Our data reveal that OXT from the peripheral nervous system is an endogenous regulator of adipose and systemic metabolism.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalNature
Volume625
Issue number7993
DOIs
StatePublished - Jan 4 2024

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