TY - JOUR
T1 - Control of bithorax complex functions by the segmentation gene fushi tarazu of D. melanogaster
AU - Duncan, Ian
N1 - Funding Information:
I would like to thank Elizabeth Burgess, John Duncan, Joel Eissen-berg, Eric Schroeter, Esther Siegfried, and the anonymous reviewers for critical reviews of the manuscript. Ken Kemphues, Tom Kaufman, E. B Lewis, Shige Sakonju, and Eric Wieschaus provided stocks important to the study. Special thanks go to E. B. Lewis for his generosity in providing the Uall and &z/2 mutations and for first making several of the observations described in this report. Special thanks go also to Dianne Mattson for discussions, review of the manuscript, and preparation of the figures. This work was supported by grant GM32318 from the National Institutes of Health. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
PY - 1986/10/24
Y1 - 1986/10/24
N2 - The properties of three dominant alleles of ftz are described. These alleles cause transformations of the first abdominal segment to the third and cause alternate segment pattern deletions that are out of phase with respect to those caused by ftz null alleles. To explain the effects of these mutations, a model is proposed in which ftz+ has two roles: to subdivide the body into parasegments and to activate appropriate bithorax complex functions in alternate parasegments. According to this model, the effects of the novel ftz alleles can be understood as arising from a slight widening of the blastoderm stripes of ftz expression.
AB - The properties of three dominant alleles of ftz are described. These alleles cause transformations of the first abdominal segment to the third and cause alternate segment pattern deletions that are out of phase with respect to those caused by ftz null alleles. To explain the effects of these mutations, a model is proposed in which ftz+ has two roles: to subdivide the body into parasegments and to activate appropriate bithorax complex functions in alternate parasegments. According to this model, the effects of the novel ftz alleles can be understood as arising from a slight widening of the blastoderm stripes of ftz expression.
UR - http://www.scopus.com/inward/record.url?scp=0023056279&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(86)90452-6
DO - 10.1016/0092-8674(86)90452-6
M3 - Article
C2 - 2876778
AN - SCOPUS:0023056279
SN - 0092-8674
VL - 47
SP - 297
EP - 309
JO - Cell
JF - Cell
IS - 2
ER -