Contribution of invariant residues to the function of Rgg family transcription regulators

Jennifer A. Loughman, Michael G. Caparon

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalJournal of bacteriology
Volume189
Issue number2
DOIs
StatePublished - Jan 2007

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