Contralateral targeting of the corpus callosum in normal and pathological brain function

Laura R. Fenlon, Linda J. Richards

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

The corpus callosum connects the two cortical hemispheres of the mammalian brain and is susceptible to structural defects during development, which often result in significant neuropsychological dysfunction. To date, such individuals have been studied primarily with regards to the integrity of the callosal tract at the midline. However, the mechanisms regulating the contralateral targeting of the corpus callosum, after midline crossing has occurred, are less well understood. Recent evidence suggests that defects in contralateral targeting can occur in isolation from midline-tract malformations, and may have significant functional implications. We propose that contralateral targeting is a crucially important and relatively under-investigated event in callosal development, and that defects in this process may constitute an undiagnosed phenotype in several neurological disorders.

Original languageEnglish
Pages (from-to)264-272
Number of pages9
JournalTrends in Neurosciences
Volume38
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Autism
  • Brain development
  • Callosal dysgenesis
  • Contralateral targeting
  • Corpus callosum
  • Schizophrenia

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