Continuous Renal Replacement Therapy for Two Neonates With Hyperammonemia

Christopher Markham, Caroline Williams, Cory Miller, Dorothy K. Grange, T. Keefe Davis, Kenneth E. Remy

Research output: Contribution to journalReview articlepeer-review

Abstract

Objectives: This study aims to assess the feasibility of using hemofiltration for ammonia clearance in low body weight infants with an inborn error of metabolism. Design: A study of two cases. Setting: Quaternary pediatric hospital (Saint Louis Children's Hospital) NICU and PICU. Patients: Infants <6 months of age with an ICD-9 diagnosis of 270.6 (hyperammonemia). Interventions: Continuous renal replacement therapy (CRRT). Measurements and Main Results: We measure serum ammonia levels over time and the rate of ammonia clearance over time. Continuous renal replacement therapy was more effective than scavenger therapy alone (Ammonul™) for rapid removal of ammonia in low weight infants (as low as 2.5 kg). Conclusions: Continuous renal replacement therapy is technically feasible in low weight infants with severe hyperammonemia secondary to an inborn error of metabolism.

Original languageEnglish
Article number732354
JournalFrontiers in Pediatrics
Volume9
DOIs
StatePublished - Nov 5 2021

Keywords

  • citrullinemia
  • hemodialysis
  • hyperammonemia
  • methylmalonic acidemia
  • neonate

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