Continuous arteriovenous hemofiltration does not improve survival in a canine model of septic shock

B. D. Freeman, I. Yatsiv, C. Natanson, M. A. Solomon, Z. M.N. Quezado, R. L. Danner, S. M. Banks, W. D. Hoffman

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

BACKGROUND: We examined whether or not continuous arteriovenous hemofiltration (CAVH), in the absence of renal failure, would improve either hemodynamic abnormalities or survival in a canine model of septic shock. STUDY DESIGN: Escherichia coli 0111, as an intraperitoneal clot, was surgically implanted into 21 one- to two-year-old purpose-bred beagles. The dogs were randomized to no CAVH (control group, n=7), sham CAVH (extracorporeal circulation without hemofiltration, n=7), or true CAVH (hemofiltration with removal of 600 mL/hour of ultrafiltrate, n=7). Hemofiltration began one hour after clot implantation and continued for six hours. All dogs received antibiotics and had serial hemodynamic and laboratory evaluations. RESULTS: During the first seven hours of the study, all dogs displayed a progressive, significant decrease in mean arterial pressure, cardiac index, left ventricular ejection fraction, and serum pH (all p<0.05). Two of seven dogs in the control group, one of seven dogs in the sham CAVH group, and one of seven dogs in the true CAVH group survived seven days after clot implantation. True CAVH, which included fluid replacement with lactated Ringer's solution, significantly increased serum lactate and decreased serum bicarbonate levels after six hours (both p<0.05). However, pH did not differ between the three treatment groups (p>0.20). Continuous arteriovenous hemofiltration therapy had no significant effect on cardiovascular abnormalities or survival. CONCLUSIONS: The results of this study suggest that CAVH would be unlikely to provide benefit to patients with gram-negative septic shock, in the absence of renal failure.

Original languageEnglish
Pages (from-to)286-292
Number of pages7
JournalJournal of the American College of Surgeons
Volume180
Issue number3
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint Dive into the research topics of 'Continuous arteriovenous hemofiltration does not improve survival in a canine model of septic shock'. Together they form a unique fingerprint.

  • Cite this

    Freeman, B. D., Yatsiv, I., Natanson, C., Solomon, M. A., Quezado, Z. M. N., Danner, R. L., Banks, S. M., & Hoffman, W. D. (1995). Continuous arteriovenous hemofiltration does not improve survival in a canine model of septic shock. Journal of the American College of Surgeons, 180(3), 286-292.