Continuous Arterial Spin Labeled Perfusion Magnetic Resonance Imaging in Patients before and after Carotid Endarterectomy

Beau M. Ances, Michael L. McGarvey, John M. Abrahams, Joseph A. Maldjian, David C. Alsop, Eric L. Zager, John A. Detre

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Continuous arterial spin labeling perfusion magnetic resonance imaging (CASL-pMRI) uses magnetically labeled arterial blood water as a tracer to obtain quantifiable measurements of cerebral blood flow (CBF) (mL/100 g -1/min-1). CASL-pMRI was used to assess CBF changes in major vascular distributions in patients (n = 10) prior to and 3 months after carotid endarterectomy (CEA). No significant change in the global baseline CBF before and after CEA was observed in the group as a whole (P = .81). In patients with reduced CBF prior to CEA (< 50 ml/100 g/min), a significant increase in global CBF following CEA was observed. An inverse relationship existed between percent change in CBF after CEA versus baseline CBF within the anterior circulation (r = -.78, P < .05) but not in the posterior distribution (r = .25, P = .63). CASL-pMRI may provide a convenient, inexpensive, noninvasive method for identifying CEA patients at risk for hyperperfusion following carotid revascularization.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of Neuroimaging
Volume14
Issue number2
DOIs
StatePublished - Apr 2004

Keywords

  • Carotid endarterectomy
  • Carotid stenosis
  • Cerebral blood flow
  • Magnetic resonance imaging

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