TY - JOUR
T1 - Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course
AU - the ACTION Consortium
AU - van der Laan, Camiel M.
AU - Morosoli-García, José J.
AU - van de Weijer, Steve G.A.
AU - Colodro-Conde, Lucía
AU - Ip, Hill F.
AU - van der Laan, Camiel M.
AU - Krapohl, Eva M.L.
AU - Brikell, Isabell
AU - Sánchez-Mora, Cristina
AU - Nolte, Ilja M.
AU - Pourcain, Beate St
AU - Bolhuis, Koen
AU - Palviainen, Teemu
AU - Zafarmand, Hadi
AU - Gordon, Scott
AU - Zayats, Tetyana
AU - Aliev, Fazil
AU - Jiang, Chang
AU - Wang, Carol A.
AU - Saunders, Gretchen
AU - Karhunen, Ville
AU - Hammerschlag, Anke R.
AU - Adkins, Daniel E.
AU - Border, Richard
AU - Peterson, Roseann E.
AU - Prinz, Joseph A.
AU - Thiering, Elisabeth
AU - Seppälä, Ilkka
AU - Vilor-Tejedor, Natàlia
AU - Ahluwalia, Tarunveer S.
AU - Day, Felix R.
AU - Allegrini, Andrea G.
AU - Rimfeld, Kaili
AU - Chen, Qi
AU - Lu, Yi
AU - Martin, Joanna
AU - Artigas, María Soler
AU - Rovira, Paula
AU - Bosch, Rosa
AU - Español, Gemma
AU - Quiroga, Josep Antoni Ramos
AU - Neumann, Alexander
AU - Ensink, Judith
AU - Grasby, Katrina
AU - Tong, Xiaoran
AU - Marrington, Shelby
AU - Middeldorp, Christel
AU - Scott, James G.
AU - Vinkhuyzen, Anna
AU - Shabalin, Andrey A.
AU - Corley, Robin
AU - Evans, Luke M.
AU - Sugden, Karen
AU - Alemany, Silvia
AU - Sass, Lærke
AU - Vinding, Rebecca
AU - Ruth, Kate
AU - Tyrrell, Jess
AU - Ehli, Erik A.
AU - Hagenbeek, Fiona A.
AU - De Zeeuw, Eveline
AU - Van Beijsterveldt, Toos C.E.M.
AU - Larsson, Henrik
AU - Snieder, Harold
AU - Verhulst, Frank C.
AU - Amin, Najaf
AU - Whipp, Alyce M.
AU - Korhonen, Tellervo
AU - Vuoksimaa, Eero
AU - Rose, Richard J.
AU - Uitterlinden, André G.
AU - Heath, Andrew C.
AU - Madden, Pamela
AU - Haavik, Jan
AU - Harris, Jennifer R.
AU - Helgeland, Øyvind
AU - Johansson, Stefan
AU - Knudsen, Gun Peggy S.
AU - Njolstad, Pal Rasmus
AU - Lu, Qing
AU - Rodriguez, Alina
AU - Henders, Anjali K.
AU - Mamun, Abdullah
AU - Najman, Jackob M.
AU - Brown, Sandy
AU - Hopfer, Christian
AU - Krauter, Kenneth
AU - Reynolds, Chandra
AU - Smolen, Andrew
AU - Stallings, Michael
AU - Wadsworth, Sally
AU - Wall, Tamara L.
AU - Silberg, Judy L.
AU - Miller, Allison
AU - Keltikangas-Järvinen, Liisa
AU - Hakulinen, Christian
AU - Pulkki-Råback, Laura
AU - Havdahl, Alexandra
AU - Magnus, Per
AU - Raitakari, Olli T.
AU - Perry, John R.B.
AU - Llop, Sabrina
AU - Lopez-Espinosa, Maria Jose
AU - Bønnelykke, Klaus
AU - Bisgaard, Hans
AU - Sunyer, Jordi
AU - Lehtimäki, Terho
AU - Arseneault, Louise
AU - Standl, Marie
AU - Heinrich, Joachim
AU - Boden, Joseph
AU - Pearson, John
AU - Horwood, LJohn J.
AU - Kennedy, Martin
AU - Poulton, Richie
AU - Eaves, Lindon J.
AU - Maes, Hermine H.
AU - Hewitt, John
AU - Copeland, William E.
AU - Costello, Elizabeth J.
AU - Williams, Gail M.
AU - Wray, Naomi
AU - Järvelin, Marjo Riitta
AU - McGue, Matt
AU - Iacono, William
AU - Caspi, Avshalom
AU - Moffitt, Terrie E.
AU - Whitehouse, Andrew
AU - Pennell, Craig E.
AU - Klump, Kelly L.
AU - Burt, S. Alexandra
AU - Dick, Danielle M.
AU - Reichborn-Kjennerud, Ted
AU - Vrijkotte, Tanja
AU - Kaprio, Jaakko
AU - Tiemeier, Henning
AU - Smith, George Davey
AU - Hartman, Catharina A.
AU - Oldehinkel, Albertine J.
AU - Casas, Miquel
AU - Ribasés, Marta
AU - Lichtenstein, Paul
AU - Lundström, Sebastian
AU - Plomin, Robert
AU - Bartels, Meike
AU - Lupton, Michelle K.
AU - Mitchell, Brittany L.
AU - McAloney, Kerrie
AU - Parker, Richard
AU - Burns, Jane M.
AU - Hickie, Ian B.
AU - Pool, René
AU - Hottenga, Jouke Jan
AU - Martin, Nicholas G.
AU - Medland, Sarah E.
AU - Nivard, Michel G.
AU - Boomsma, Dorret I.
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/9
Y1 - 2021/9
N2 - We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
AB - We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
KW - Aggression
KW - Aggressive behavior
KW - Development
KW - Life-course
KW - Polygenic score
KW - Rolling weights
UR - http://www.scopus.com/inward/record.url?scp=85116861074&partnerID=8YFLogxK
U2 - 10.1007/s10519-021-10076-6
DO - 10.1007/s10519-021-10076-6
M3 - Article
C2 - 34390460
AN - SCOPUS:85116861074
SN - 0001-8244
VL - 51
SP - 592
EP - 606
JO - Behavior genetics
JF - Behavior genetics
IS - 5
ER -