Contemporary Use of Venoarterial Extracorporeal Membrane Oxygenation: Insights from the Multicenter RESCUE Registry

Rahul S. Loungani, Marat Fudim, Dave Ranney, Ajar Kochar, Marc D. Samsky, Desiree Bonadonna, Akinobu Itoh, Hiroo Takayama, Koji Takeda, Daniel Wojdyla, Adam D. DeVore, Mani Daneshmand

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as a life-saving therapy for patients with cardiovascular collapse, but identifying patients unlikely to benefit remains a challenge. Methods and Results: We created the RESCUE registry, a retrospective, observational registry of adult patients treated with VA-ECMO between January 2007 and June 2017 at 3 high-volume centers (Columbia University, Duke University, and Washington University) to describe short-term patient outcomes. In 723 patients treated with VA-ECMO, the most common indications for deployment were postcardiotomy shock (31%), cardiomyopathy (including acute heart failure) (26%), and myocardial infarction (17%). Patients frequently suffered in-hospital complications, including acute renal dysfunction (45%), major bleeding (41%), and infection (33%). Only 40% of patients (n = 290) survived to discharge, with a minority receiving durable cardiac support (left ventricular assist device [n = 48] or heart transplantation [n = 7]). Multivariable regression analysis identified risk factors for mortality on ECMO as older age (odds ratio [OR], 1.26; 95% confidence interval [CI], 1.12–1.42) and female sex (OR, 1.44; 95% CI, 1.02–2.02) and risk factors for mortality after decannulation as higher body mass index (OR 1.17; 95% CI, 1.01-1.35) and major bleeding while on ECMO support (OR, 1.92; 95% CI, 1.23–2.99). Conclusions: Despite contemporary care at high-volume centers, patients treated with VA-ECMO continue to have significant in-hospital morbidity and mortality. The optimization of outcomes will require refinements in patient selection and improvement of care delivery.

Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalJournal of cardiac failure
Volume27
Issue number3
DOIs
StatePublished - Mar 2021

Keywords

  • Cardiogenic shock
  • mechanical circulatory support
  • venoarterial extracorporeal membrane oxygenation

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