Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

Keyphrases

• Active Variants 16%
• Amyotrophic Lateral Sclerosis 100%
• Autoinhibition 16%
• Axon 8%
• Axonal Loss 8%
• Constitutively Active 100%
• Cultured Neurons 8%
• Dorsal Root Ganglion Neurons 8%
• Enzymatic Activity 8%
• Fold Enrichment 8%
• Genetic Risk 8%
• Human Variants 8%
• Hydrolases 8%
• In-frame Deletion 8%
• Intrathecal Injection 8%
• Missense Variants 8%
• Motor Dysfunction 8%
• Multiple Patients 8%
• NADase 8%
• Neurodegeneration 8%
• Neurodegenerative Conditions 8%
• Neurodegenerative Diseases 8%
• Neuroinflammation 8%
• Neuropathy 100%
• Nicotinamide Adenine Dinucleotide (NAD+) 8%
• Reference Allele 8%
• Response to Injury 8%
• SARM1 100%
• Self-destruction 8%
• Single Amino Acid Substitution 8%
• Virus 8%

Neuroscience

• Adeno-Associated Virus 14%
• Amino Acid 14%
• Amyotrophic Lateral Sclerosis 100%
• Axon 28%
• Dorsal Root Ganglion 14%
• Enzyme Activity 14%
• Hydrolase 14%
• In Vivo 14%
• Intrathecal 14%
• Neurodegeneration 14%
• Neurodegenerative Disorder 14%
• Neuropathy 100%
• Nicotinamide Adenine Dinucleotide Nucleosidase 14%
• Stereotypic Movement Disorder 14%

Biochemistry, Genetics and Molecular Biology

• Allele 100%
• Amino Acids 25%
• Autoinhibition 50%
• Axon 50%
• Enzyme 25%
• Enzyme Activity 25%
• Genetic Risk 25%
• Hydrolase 25%
• Missense 25%
• Nerve Cell Culture 25%