Considerations in the evaluation of haemophilia patients for short-term prophylactic therapy: A paediatric and adult case study

L. Luchtman-Jones; L. A. Valentino; C. Manno; Geoffrey Allen; Morey Blinder; Lisa Boggio; Clark Brown; Alan Cohen; Kathy Fu; Michael Jeng; Nathan Kobrinsky; Eric Kraut; Roshni Kulkarni; Jeanne Lusher; Prasad Mathew; Dana Matthews; Steven Pipe; Doris Quon; Ashok Raj; Jagadeesh Ramdas; Hernan Sabio; Lance Sieger; Michael Tapper; David Ungar; Brian Wickland

doi:10.1111/j.1365-2516.2005.01171.x

Considerations in the evaluation of haemophilia patients for short-term prophylactic therapy: A paediatric and adult case study

L. Luchtman-Jones, L. A. Valentino, C. Manno, Geoffrey Allen, Morey Blinder, Lisa Boggio, Clark Brown, Alan Cohen, Kathy Fu, Michael Jeng, Nathan Kobrinsky, Eric Kraut, Roshni Kulkarni, Jeanne Lusher, Prasad Mathew, Dana Matthews, Steven Pipe, Doris Quon, Ashok Raj, Jagadeesh RamdasHernan Sabio, Lance Sieger, Michael Tapper, David Ungar, Brian Wickland

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The long-term prophylactic administration of clotting factor concentrate in patients with haemophilia reduces bleeding events, slows joint deterioration, and improves quality of life. Prophylaxis can also be effective when used short-term to prevent or reduce bleeding associated with trauma, surgery, and athletic activities. While clinical trials are needed to establish the optimal length of prophylaxis following injury, several weeks and possibly months of treatment may be needed. Discontinuing therapy prematurely can result in rebleeding in the injured area.

Original language	English
Pages (from-to)	82-86
Number of pages	5
Journal	Haemophilia
Volume	12
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2516.2005.01171.x
State	Published - Jan 2006

Keywords

Haematoma
Intracranial haemorrhage
Primary prophylaxis
Prophylaxis
Secondary prophylaxis
Severe haemophilia A
Short-term prophylaxis

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Luchtman-Jones, L., Valentino, L. A., Manno, C., Allen, G., Blinder, M., Boggio, L., Brown, C., Cohen, A., Fu, K., Jeng, M., Kobrinsky, N., Kraut, E., Kulkarni, R., Lusher, J., Mathew, P., Matthews, D., Pipe, S., Quon, D., Raj, A., ... Wickland, B. (2006). Considerations in the evaluation of haemophilia patients for short-term prophylactic therapy: A paediatric and adult case study. Haemophilia, 12(1), 82-86. https://doi.org/10.1111/j.1365-2516.2005.01171.x

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abstract = "The long-term prophylactic administration of clotting factor concentrate in patients with haemophilia reduces bleeding events, slows joint deterioration, and improves quality of life. Prophylaxis can also be effective when used short-term to prevent or reduce bleeding associated with trauma, surgery, and athletic activities. While clinical trials are needed to establish the optimal length of prophylaxis following injury, several weeks and possibly months of treatment may be needed. Discontinuing therapy prematurely can result in rebleeding in the injured area.",

keywords = "Haematoma, Intracranial haemorrhage, Primary prophylaxis, Prophylaxis, Secondary prophylaxis, Severe haemophilia A, Short-term prophylaxis",

author = "L. Luchtman-Jones and Valentino, {L. A.} and C. Manno and Geoffrey Allen and Morey Blinder and Lisa Boggio and Clark Brown and Alan Cohen and Kathy Fu and Michael Jeng and Nathan Kobrinsky and Eric Kraut and Roshni Kulkarni and Jeanne Lusher and Prasad Mathew and Dana Matthews and Steven Pipe and Doris Quon and Ashok Raj and Jagadeesh Ramdas and Hernan Sabio and Lance Sieger and Michael Tapper and David Ungar and Brian Wickland",

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doi = "10.1111/j.1365-2516.2005.01171.x",

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Luchtman-Jones, L, Valentino, LA, Manno, C, Allen, G, Blinder, M, Boggio, L, Brown, C, Cohen, A, Fu, K, Jeng, M, Kobrinsky, N, Kraut, E, Kulkarni, R, Lusher, J, Mathew, P, Matthews, D, Pipe, S, Quon, D, Raj, A, Ramdas, J, Sabio, H, Sieger, L, Tapper, M, Ungar, D & Wickland, B 2006, 'Considerations in the evaluation of haemophilia patients for short-term prophylactic therapy: A paediatric and adult case study', Haemophilia, vol. 12, no. 1, pp. 82-86. https://doi.org/10.1111/j.1365-2516.2005.01171.x

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AU - Luchtman-Jones, L.

AU - Valentino, L. A.

AU - Manno, C.

AU - Allen, Geoffrey

AU - Blinder, Morey

AU - Boggio, Lisa

AU - Brown, Clark

AU - Cohen, Alan

AU - Fu, Kathy

AU - Jeng, Michael

AU - Kobrinsky, Nathan

AU - Kraut, Eric

AU - Kulkarni, Roshni

AU - Lusher, Jeanne

AU - Mathew, Prasad

AU - Matthews, Dana

AU - Pipe, Steven

AU - Quon, Doris

AU - Raj, Ashok

AU - Ramdas, Jagadeesh

AU - Sabio, Hernan

AU - Sieger, Lance

AU - Tapper, Michael

AU - Ungar, David

AU - Wickland, Brian

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KW - Intracranial haemorrhage

KW - Primary prophylaxis

KW - Prophylaxis

KW - Secondary prophylaxis

KW - Severe haemophilia A

KW - Short-term prophylaxis

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Considerations in the evaluation of haemophilia patients for short-term prophylactic therapy: A paediatric and adult case study

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Keywords

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