Conserved oligomeric golgi and neuronal vesicular trafficking

Leslie K. Climer, Rachel D. Hendrix, Vladimir V. Lupashin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations

Abstract

The conserved oligomeric Golgi (COG) complex is an evolutionary conserved multi-subunit vesicle tethering complex essential for the majority of Golgi apparatus functions: protein and lipid glycosylation and protein sorting. COG is present in neuronal cells, but the repertoire of COG function in different Golgi-like compartments is an enigma. Defects in COG subunits cause alteration of Golgi morphology, protein trafficking, and glycosylation resulting in human congenital disorders of glycosylation (CDG) type II. In this review we summarize and critically analyze recent advances in the function of Golgi and Golgi-like compartments in neuronal cells and functions and dysfunctions of the COG complex and its partner proteins.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages227-247
Number of pages21
DOIs
StatePublished - 2018

Publication series

NameHandbook of Experimental Pharmacology
Volume245
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • COG
  • Conserved oligomeric Golgi
  • Glycosylation
  • Golgi outpost
  • Golgi satellite

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