TY - JOUR
T1 - Consequences of congenital Zika virus infection
AU - Platt, Derek J.
AU - Miner, Jonathan J.
N1 - Funding Information:
J.J.M. is supported by grants from the NIH ( K08AR070918 and R21EY027870 ), a Department of Defense Discovery Award ( W81XWH171011 ), Mid-America Transplant, the Children's Discovery Institute ( MIII2017646 ), and the Rheumatology Research Foundation. D.J.P. is supported by the Washington University Chancellors Graduate Fellowship Program and the NIH Initiative to Maximize Student Development (5R25GM103757).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/12
Y1 - 2017/12
N2 - The 2015 Zika virus (ZIKV) epidemic in the Americas led to the discovery that ZIKV causes congenital abnormalities including microcephaly, intrauterine growth restriction, and eye disease that can result in blindness. Studies in animal models and human organoid cultures, together with human epidemiological studies, have shown that ZIKV crosses the placenta and subsequently replicates within fetal tissues including the developing brain. Preferential infection of neural cell precursors causes damage to the developing fetal brain. However, a majority of congenitally infected humans do not develop microcephaly or other overt congenital abnormalities, so longitudinal epidemiological studies are necessary to more completely define the long-term consequences of in utero ZIKV infection.
AB - The 2015 Zika virus (ZIKV) epidemic in the Americas led to the discovery that ZIKV causes congenital abnormalities including microcephaly, intrauterine growth restriction, and eye disease that can result in blindness. Studies in animal models and human organoid cultures, together with human epidemiological studies, have shown that ZIKV crosses the placenta and subsequently replicates within fetal tissues including the developing brain. Preferential infection of neural cell precursors causes damage to the developing fetal brain. However, a majority of congenitally infected humans do not develop microcephaly or other overt congenital abnormalities, so longitudinal epidemiological studies are necessary to more completely define the long-term consequences of in utero ZIKV infection.
UR - http://www.scopus.com/inward/record.url?scp=85032196624&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2017.09.005
DO - 10.1016/j.coviro.2017.09.005
M3 - Review article
C2 - 29080429
AN - SCOPUS:85032196624
VL - 27
SP - 1
EP - 7
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
ER -