TY - JOUR
T1 - Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care
T2 - A statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine
AU - Le Roux, Peter
AU - Menon, David K.
AU - Citerio, Giuseppe
AU - Vespa, Paul
AU - Bader, Mary Kay
AU - Brophy, Gretchen M.
AU - Diringer, Michael N.
AU - Stocchetti, Nino
AU - Videtta, Walter
AU - Armonda, Rocco
AU - Badjatia, Neeraj
AU - Böesel, Julian
AU - Chesnut, Randall
AU - Chou, Sherry
AU - Claassen, Jan
AU - Czosnyka, Marek
AU - De Georgia, Michael
AU - Figaji, Anthony
AU - Fugate, Jennifer
AU - Helbok, Raimund
AU - Horowitz, David
AU - Hutchinson, Peter
AU - Kumar, Monisha
AU - McNett, Molly
AU - Miller, Chad
AU - Naidech, Andrew
AU - Oddo, Mauro
AU - Olson, Dai Wai
AU - O'Phelan, Kristine
AU - Provencio, J. Javier
AU - Puppo, Corinna
AU - Riker, Richard
AU - Robertson, Claudia
AU - Schmidt, Michael
AU - Taccone, Fabio
N1 - Funding Information:
Conflicts of interest Each author and each member of the jury reported any potential conflicts of interest (COI). The author and NCS Guideline Committee Chairs determined any required resolutions according to NCS COI process and resolution guidelines before appointment to the writing committee. The following methods were used to resolve any potential COI: (1) Perform peer review for evidence-based content, (2) provide faculty with alternate topic, (3) provide alternate faculty for specific topics, (4) limit content to evidence with no recommendations, (5) perform review of all materials associated with the activity by planning committee, (6) abstain from discussions related to the conflict, (7) abstain from voting related to the conflict, (8) request reassignment to a committee that will not result in a conflict. NCS Guidelines state: ‘‘The chair or co-chairs cannot have any financial or other important conflicts of interest related to the guideline topic.’’ PLR proposed the subject and initiated the project and therefore was appointed chair by the NCS. To be compliant with NCS Guidelines he did not vote on any of the recommendations that followed jury deliberations because of potential COI associated with industry relationships. Peter Le Roux receives research funding from Integra Lifesciences, Neurologica, the Dana Foundation, and the National Institutes of Health (NIH); is a consultant for Integra Lifesciences, Codman, Synthes, and Neurologica; and is a member of the scientific advisory board of Cerebrotech, Brainsgate, Orsan, and Edge Therapeutics. Mary Kay Bader receives honoraria from Bard, The Medicines Company, and Neuroptics and has Stock options in Neuroptics. Neeraj Badjatia receives consulting fees from Bard and Medivance and is a Scientific Advisor to Cumberland Pharmaceuticals. Julian Boesel receives honoraria from Covidien, Sedana Medical, and Orion Pharma. Gretchen Brophy receives research funding from the NIH and the Department of Defense (DoD); is on the scientific advisory board of Edge Therapeutics; has acted as a consultant for CSL Behring; and has received honoraria from UCB Pharma. Sherry Chou receives research funding from the NIH and Novartis. Giuseppe Citerio receives speaker honoraria from Codman and has received research funding from Italian government agencies (AIFA, Ministero Salute, Regione Lombardia). Marek Czosnyka is a consultant for Cambridge Enterprise Ltd and serves on the Speakers Bureau for Bard Medical. Michael Diringer receives research funding from the NIH and the AHA and is a consultant for Cephalogics LLC. Monisha Kumar receives research funding from Haemonetics. Molly McNett is a consultant for Bard Medivance and a scientific advisor for Cumberland Pharmaceuticals. David Menon has acted as a consultant or a member of Steering or Data Management Committees for Solvay Ltd, GlaxoSmithKline Ltd, Brainscope Ltd, Ornim Medical, Shire Medical, and Neurovive Ltd. J. Javier Provencio receives research funding from the NIH, Bard Medivance, and Advanced Circulatory Systems, and is on the scientific advisory board of Edge Therapeutics and Minnetronix. Nino Stocchetti is a consultant for Orsan.
Funding Information:
Paul Vespa receives grant funding from the NIH, DOD; is a consultant for Edge Therapeutics; and has Stock Options with Intouch Health. Walter Videtta receives NIH funding. Rocco Armondo, Randall Chesnut, Jan Classen, Michael De Georgia, Anthony Figaji, Jennifer Fugate, Raimund Helbok, David Horowitz, Peter Hutchinson, Chad Miller, Andrew Naidech, Mauro Oddo, DaiWai Olson, Kristine O’Phelan, Corinna Puppo, Richard Riker, Claudia Robertson, Michael Schmidt, Fabio Taccone have declared no conflicts of interest.
PY - 2014/9
Y1 - 2014/9
N2 - Neurocritical care depends, in part, on careful patient monitoring but as yet there are little data on what processes are the most important to monitor, how these should be monitored, and whether monitoring these processes is cost-effective and impacts outcome. At the same time, bioinformatics is a rapidly emerging field in critical care but as yet there is little agreement or standardization on what information is important and how it should be displayed and analyzed. The Neurocritical Care Society in collaboration with the European Society of Intensive Care Medicine, the Society for Critical Care Medicine, and the Latin America Brain Injury Consortium organized an international, multidisciplinary consensus conference to begin to address these needs. International experts from neurosurgery, neurocritical care, neurology, critical care, neuroanesthesiology, nursing, pharmacy, and informatics were recruited on the basis of their research, publication record, and expertise. They undertook a systematic literature review to develop recommendations about specific topics on physiologic processes important to the care of patients with disorders that require neurocritical care. This review does not make recommendations about treatment, imaging, and intraoperative monitoring. A multidisciplinary jury, selected for their expertise in clinical investigation and development of practice guidelines, guided this process. The GRADE system was used to develop recommendations based on literature review, discussion, integrating the literature with the participants' collective experience, and critical review by an impartial jury. Emphasis was placed on the principle that recommendations should be based on both data quality and on trade-offs and translation into clinical practice. Strong consideration was given to providing pragmatic guidance and recommendations for bedside neuromonitoring, even in the absence of high quality data.
AB - Neurocritical care depends, in part, on careful patient monitoring but as yet there are little data on what processes are the most important to monitor, how these should be monitored, and whether monitoring these processes is cost-effective and impacts outcome. At the same time, bioinformatics is a rapidly emerging field in critical care but as yet there is little agreement or standardization on what information is important and how it should be displayed and analyzed. The Neurocritical Care Society in collaboration with the European Society of Intensive Care Medicine, the Society for Critical Care Medicine, and the Latin America Brain Injury Consortium organized an international, multidisciplinary consensus conference to begin to address these needs. International experts from neurosurgery, neurocritical care, neurology, critical care, neuroanesthesiology, nursing, pharmacy, and informatics were recruited on the basis of their research, publication record, and expertise. They undertook a systematic literature review to develop recommendations about specific topics on physiologic processes important to the care of patients with disorders that require neurocritical care. This review does not make recommendations about treatment, imaging, and intraoperative monitoring. A multidisciplinary jury, selected for their expertise in clinical investigation and development of practice guidelines, guided this process. The GRADE system was used to develop recommendations based on literature review, discussion, integrating the literature with the participants' collective experience, and critical review by an impartial jury. Emphasis was placed on the principle that recommendations should be based on both data quality and on trade-offs and translation into clinical practice. Strong consideration was given to providing pragmatic guidance and recommendations for bedside neuromonitoring, even in the absence of high quality data.
KW - Bioinformatics
KW - Biomarkers
KW - Brain metabolism
KW - Brain oxygen
KW - Brain physiology
KW - Clinical guidelines
KW - Clinical trials
KW - Consensus development conference
KW - Grading of Recommendations Assessment Development and Evaluation (GRADE)
KW - Intracranial pressure
KW - Microdialysis
KW - Multimodal monitoring
KW - Neurocritical care
KW - Neuromonitoring
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84906939768&partnerID=8YFLogxK
U2 - 10.1007/s00134-014-3369-6
DO - 10.1007/s00134-014-3369-6
M3 - Review article
C2 - 25138226
AN - SCOPUS:84906939768
SN - 0342-4642
VL - 40
SP - 1189
EP - 1209
JO - Intensive care medicine
JF - Intensive care medicine
IS - 9
ER -