Background: BK channel function is differentially modulated by tissue-specific β (β1-4) subunits. Results: Conopeptide Vt3.1 preferentially inhibits neuronal BK channels containing the β4 subunit. Conclusion: Electrostatic interactions between Vt3.1 and the extracellular loop of β4 decrease voltage-dependent activation of the channel. Significance: Vt3.1 is an excellent tool for studying the structure, function, and roles in neurophysiology of BK channels.
|Number of pages||8|
|Journal||Journal of Biological Chemistry|
|State||Published - Feb 21 2014|