Connections of orbital cortex

Joseph L. Price

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


This chapter describes the connections of the orbital and medial prefrontal cortex. Intrinsic connections indicate the presence of distinct orbital and medial networks, with the orbital network concentrated in central OFC subregions, and the medial network involving medial structures, and some areas on the medial and lateral orbital surface. The medial and orbital networks show strikingly differential patterns of input and output. The orbital network receives substantial input from sensory systems including olfaction, taste, visceral, visual, and somatosensory systems, and may serve to assess sensory objects, especially food. The medial network has little direct sensory input, but provides output to the hypothalamus and periaqueductal gray, and is heavily connected with limbic regions such as the amygdala, entorhinal cortex, and hippocampus. The medial and orbital networks are also connected to distinct parts of the striatum and mediodorsal thalamic nucleus.

Original languageEnglish
Title of host publicationThe Orbitofrontal Cortex
PublisherOxford University Press
Number of pages20
ISBN (Electronic)9780191723971
ISBN (Print)0198565747, 9780198565741
StatePublished - Feb 1 2010


  • Amygdala
  • Entorhinal cortex
  • Hippocampus
  • Hypothalamus
  • Limbic
  • Network
  • Projections
  • Sensory
  • Thalamus


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