TY - JOUR
T1 - Conjunctival lymphocytic nodule associated with the Epstein-Barr virus
AU - Gardner, B. P.
AU - Margolis, T. P.
AU - Mondino, B. J.
N1 - Funding Information:
From the Jules Stein Eye Institute and Departments of Ophthalmology (Drs. Gardner, Margolis, and Mondino) and Microbiology & Immunology (Dr. Margolis), University of California, Los Angeles Medical Center, Los Angeles, California. This study was supported in part by National Institutes of Health grants EY06190 (Dr. Margolis) and EY04606 (Dr. Mondino).
PY - 1991
Y1 - 1991
N2 - Infection with Epstein-Barr virus has been reported to have numerous systemic and ocular manifestations. In this study, a 38-year-old man with acute infectious mononucleosis was examined for a painless left red eye of three days' duration. The patient had a two-week history of fatigue, low-grade fever, sore throat, and lymphadenopathy. Serologic evaluation was indicative of an acute primary infection with Epstein-Barr virus. A large, salmon-colored, supranasal bulbar conjunctival mass was observed in the left eye. No associated conjunctivitis was present. Biopsy of the conjunctival lesion disclosed a dense leukocytic infiltrate, which consisted primarily of mature lymphocytes and plasma cells. Immunocytochemical evaluation of the tissue with monoclonal antisera disclosed Epstein-Barr latent membrane protein and nuclear protein 2 in a small fraction of the cells constituting the infiltrate. The conjunctival infiltrate resolved completely within one month, paralleling the regression of the patient's lymphadenopathy.
AB - Infection with Epstein-Barr virus has been reported to have numerous systemic and ocular manifestations. In this study, a 38-year-old man with acute infectious mononucleosis was examined for a painless left red eye of three days' duration. The patient had a two-week history of fatigue, low-grade fever, sore throat, and lymphadenopathy. Serologic evaluation was indicative of an acute primary infection with Epstein-Barr virus. A large, salmon-colored, supranasal bulbar conjunctival mass was observed in the left eye. No associated conjunctivitis was present. Biopsy of the conjunctival lesion disclosed a dense leukocytic infiltrate, which consisted primarily of mature lymphocytes and plasma cells. Immunocytochemical evaluation of the tissue with monoclonal antisera disclosed Epstein-Barr latent membrane protein and nuclear protein 2 in a small fraction of the cells constituting the infiltrate. The conjunctival infiltrate resolved completely within one month, paralleling the regression of the patient's lymphadenopathy.
UR - http://www.scopus.com/inward/record.url?scp=0026072624&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(14)76860-6
DO - 10.1016/S0002-9394(14)76860-6
M3 - Article
C2 - 1659201
AN - SCOPUS:0026072624
SN - 0002-9394
VL - 112
SP - 567
EP - 571
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -