TY - JOUR
T1 - Conjunctival Cytologiec Features of Primary Sjögren's Syndrome
AU - Pflugfelder, Stephen C.
AU - Huang, Andrew J.W.
AU - Feuer, William
AU - Chuchovski, Plinio T.
AU - Pereira, Ivonildo C.
AU - Tseng, Scheffer C.G.
N1 - Funding Information:
Supported in part by Public Health Service research grant #EY02180; in part by BRSG S07 RR-05363 (Dr. Pflugfelder), Biomedical Research Support Grant Programs, National Institutes of Health, National Eye Institute; and in part by Fight-for-Sight-Prevent Blindness Grant-in-Aid GA 89-025 (Dr. Pflugfelder).
PY - 1990
Y1 - 1990
N2 - To determine whether there are specific cytologic features associated with primary Sjögren's syndrome (SS), the authors evaluated impression cytology specimens from three conjunctival sites (temporal bulbar [TB], inferior bulbar [IB], and inferior tarsal [IT]) from 38 SS eyes, 34 eyes of aqueous tear-deficient patients without SS, 35 eyes of seborrheic blepharitis patients, and 17 eyes of normal controls in a masked fashion. The following features were observed more frequently in SS eyes than in the eyes of the other groups: squamous metaplasia of the TB and IB (P < 0.05), extensive (>75%) goblet cell loss of the TB (P < 0.05), mucous aggregates of the bulbar conjunctiva (P < 0.05), and inflammatory cells intercalated with epithelial cells on the IT conjunctiva (P < 0.06). The conjunctival inflammatory cell infiltrate correlated with the presence of extensive squamous metaplasia (P < 0.01) in SS specimens. The inflammatory cells on the IT conjunctival epithelium were found to consist predominantly of T-lymphocytes by immunofluorescent staining of cytologic specimens from six eyes. Based on these findings, the authors speculated that conjunctival squamous metaplasia, in addition to aqueous tear deficiency, may be due to primary involvement of the dysfunctional immune system of SS.
AB - To determine whether there are specific cytologic features associated with primary Sjögren's syndrome (SS), the authors evaluated impression cytology specimens from three conjunctival sites (temporal bulbar [TB], inferior bulbar [IB], and inferior tarsal [IT]) from 38 SS eyes, 34 eyes of aqueous tear-deficient patients without SS, 35 eyes of seborrheic blepharitis patients, and 17 eyes of normal controls in a masked fashion. The following features were observed more frequently in SS eyes than in the eyes of the other groups: squamous metaplasia of the TB and IB (P < 0.05), extensive (>75%) goblet cell loss of the TB (P < 0.05), mucous aggregates of the bulbar conjunctiva (P < 0.05), and inflammatory cells intercalated with epithelial cells on the IT conjunctiva (P < 0.06). The conjunctival inflammatory cell infiltrate correlated with the presence of extensive squamous metaplasia (P < 0.01) in SS specimens. The inflammatory cells on the IT conjunctival epithelium were found to consist predominantly of T-lymphocytes by immunofluorescent staining of cytologic specimens from six eyes. Based on these findings, the authors speculated that conjunctival squamous metaplasia, in addition to aqueous tear deficiency, may be due to primary involvement of the dysfunctional immune system of SS.
UR - http://www.scopus.com/inward/record.url?scp=0025050542&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(90)32478-8
DO - 10.1016/S0161-6420(90)32478-8
M3 - Article
C2 - 1698273
AN - SCOPUS:0025050542
SN - 0161-6420
VL - 97
SP - 985
EP - 991
JO - Ophthalmology
JF - Ophthalmology
IS - 8
ER -