Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5

Keyphrases

• Cause of Disease 100%
• Proteasomal Degradation 100%
• Chloride Channel 100%
• Dent Disease 100%
• Conformational Defects 100%
• Transmembrane Domain 50%
• Protease 37%
• Misfolding 25%
• Intramolecular Interactions 25%
• N-terminal Region 25%
• Endoplasmic Reticulum 12%
• Unfolded Protein Response 12%
• Kidney 12%
• Renal Tubular Epithelial Cells 12%
• Study Support 12%
• Disease-causing mutations 12%
• C-terminal Region 12%
• Recycling Endosome 12%
• Chloride 12%
• Functional Expression 12%
• 5 Gene 12%
• Truncating mutation 12%
• C-terminal Truncation 12%
• Opossum 12%
• Limited Proteolysis 12%
• Proton Transporters 12%
• CRISTAL 12%
• Proximal Tubular Cells 12%
• Intimate Interaction 12%

Biochemistry, Genetics and Molecular Biology

• Chloride Channel 100%
• Dent's Disease 100%
• C-Terminus 62%
• Protease 37%
• N-Terminus 25%
• Crystal Structure 12%
• Unfolded Protein Response 12%
• Electric Potential 12%
• Opossum 12%
• Chloride 12%
• Proteolysis 12%

Immunology and Microbiology

• Chloride Channel 100%
• Carboxy Terminal Sequence 62%
• Susceptibility 37%
• Protease 37%
• Proteinase 37%
• Amino Terminal Sequence 25%
• Unfolded Protein Response 12%
• Endoplasmic reticulum 12%
• Electric Potential 12%
• Protein Degradation 12%
• Endosome 12%
• Crystal Structure 12%
• Opossum 12%