Conducting a Clinical Trial

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


This chapter describes design and implementation considerations for clinical trials that evaluate behavioral interventions in hospice and palliative care. We discuss traditional and emerging approaches to randomization and data analysis, considering the unique challenges of the setting including the unpredictable and often stressful conditions that participants find themselves in when dealing with advanced illness and how these affect their ability to participate in prescribed and standardized study procedures. In addition, we discuss considerations for recruitment and retention of participants and methodological approaches such as intention to treat. We also explore options for economic considerations when evaluating an intervention.

Original languageEnglish
Title of host publicationBehavioral Intervention Research in Hospice and Palliative Care
Subtitle of host publicationBuilding an Evidence Base
Number of pages20
ISBN (Electronic)9780128144497
ISBN (Print)9780128144503
StatePublished - Jan 1 2019


  • Clinical trial
  • cost analysis
  • intention to treat
  • participant recruitment and retention
  • pragmatic trial
  • randomization


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