TY - JOUR
T1 - Concordance of parapapillary chorioretinal atrophy in ocular hypertension with visual field defects that accompany glaucoma development
AU - Tezel, Gülgün
AU - Dorr, David
AU - Kolker, Allan E.
AU - Wax, Martin B.
AU - Kass, Michael A.L.
N1 - Funding Information:
Supported in part by the National Eye Institute, Bethesda, MD, grant no.: EY12314. The Glaucoma Foundation, New York, New York, and an unrestricted grant to Washington University School of Medicine, Department of Ophthalmology & Visual Sciences from Research to Prevent Blindness Inc., New York, New York.
PY - 2000
Y1 - 2000
N2 - Objective: To determine whether the extent and location of progressive parapapillary chorioretinal atrophy noted in some patients with ocular hypertension are correlated with the extent and location of visual field defects that occur with progression to glaucoma. Study Design: Retrospective cohort study. Participants: Thirty patients with ocular hypertension who had progressive changes of parapapillary atrophy develop before clinically detectable optic disc or visual field damage. Main Outcome Measures: Assessment of changes in the parapapillary atrophy and visual field parameters. Methods: Baseline and follow-up optic disc photographs and visual field test results were retrospectively analyzed. The relationship between the extent of parapapillary atrophy observed during the ocular hypertension period and initial visual field abnormalities detected after glaucoma development, as well as their spatial relationship, was statistically analyzed. Results: The extent of progressive changes of the parapapillary atrophy detected during the ocular hypertension period was correlated with the extent of changes in the visual field parameters, including corrected pattern standard deviation and mean deviation measured after glaucoma development (Mantel-Haenszel chisquare test, P = 0.026, P = 0.037, respectively). In addition, the visual field abnormalities occurred in the corresponding quadrants of the progressive parapapillary atrophy. Analysis of the spatial relationship revealed that the location of progressive changes of the parapapillary atrophy was concordant with the location of visual field abnormalities in 78% of the quadrants (94 of 120 quadrants) (chi-square test, P = 0.001). Conclusions: The extent and location of visual field abnormalities that develop in ocular hypertensive eyes with progression to glaucoma exhibit a concordance with the extent and location of progressive parapapillary atrophy noted in the ocular hypertension period. This suggests the importance of detailed examination of the parapapillary area in ocular hypertensive eyes. (C) 2000 by the American Academy of Ophthalmology.
AB - Objective: To determine whether the extent and location of progressive parapapillary chorioretinal atrophy noted in some patients with ocular hypertension are correlated with the extent and location of visual field defects that occur with progression to glaucoma. Study Design: Retrospective cohort study. Participants: Thirty patients with ocular hypertension who had progressive changes of parapapillary atrophy develop before clinically detectable optic disc or visual field damage. Main Outcome Measures: Assessment of changes in the parapapillary atrophy and visual field parameters. Methods: Baseline and follow-up optic disc photographs and visual field test results were retrospectively analyzed. The relationship between the extent of parapapillary atrophy observed during the ocular hypertension period and initial visual field abnormalities detected after glaucoma development, as well as their spatial relationship, was statistically analyzed. Results: The extent of progressive changes of the parapapillary atrophy detected during the ocular hypertension period was correlated with the extent of changes in the visual field parameters, including corrected pattern standard deviation and mean deviation measured after glaucoma development (Mantel-Haenszel chisquare test, P = 0.026, P = 0.037, respectively). In addition, the visual field abnormalities occurred in the corresponding quadrants of the progressive parapapillary atrophy. Analysis of the spatial relationship revealed that the location of progressive changes of the parapapillary atrophy was concordant with the location of visual field abnormalities in 78% of the quadrants (94 of 120 quadrants) (chi-square test, P = 0.001). Conclusions: The extent and location of visual field abnormalities that develop in ocular hypertensive eyes with progression to glaucoma exhibit a concordance with the extent and location of progressive parapapillary atrophy noted in the ocular hypertension period. This suggests the importance of detailed examination of the parapapillary area in ocular hypertensive eyes. (C) 2000 by the American Academy of Ophthalmology.
UR - http://www.scopus.com/inward/record.url?scp=0033777707&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(00)00114-7
DO - 10.1016/S0161-6420(00)00114-7
M3 - Article
C2 - 10857843
AN - SCOPUS:0033777707
SN - 0161-6420
VL - 107
SP - 1194
EP - 1199
JO - Ophthalmology
JF - Ophthalmology
IS - 6
ER -