Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester

Thomas A. Ferguson; Larry A. Fish; C. Stuart Baxter; J. Gabriel Michael

doi:10.3181/00379727-171-41481

Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester

Thomas A. Ferguson
, Larry A. Fish
, C. Stuart Baxter
, J. Gabriel Michael

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.

Original language	English
Pages (from-to)	83-87
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	171
Issue number	1
DOIs	https://doi.org/10.3181/00379727-171-41481
State	Published - Oct 1982

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title = "Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester",

abstract = "12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.",

author = "Ferguson, \{Thomas A.\} and Fish, \{Larry A.\} and Baxter, \{C. Stuart\} and Michael, \{J. Gabriel\}",

year = "1982",

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AU - Ferguson, Thomas A.

AU - Fish, Larry A.

AU - Baxter, C. Stuart

AU - Michael, J. Gabriel

PY - 1982/10

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N2 - 12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.

AB - 12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.

UR - https://www.scopus.com/pages/publications/0020452248

U2 - 10.3181/00379727-171-41481

DO - 10.3181/00379727-171-41481

M3 - Article

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AN - SCOPUS:0020452248

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JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 1

ER -

Concomitant Enhancement of B-Cell Mitogenesis and Inhibition of Antibody Synthesis by a Phorbol Ester

Abstract

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